Clouston syndrome

Clouston syndrome, also known as hidrotic ectodermal dysplasia, is a rare genetic condition. It is mainly characterized by a triad of symptoms including abnormal nail growth (nail dystrophy), hair loss (alopecia), and thickened skin on the palms and soles (palmoplantar hyperkeratosis). People with this condition typically experience changes in the nails and hair as well as alterations in the skin of their hands and feet. This summary provides an overview based on established definitions of the condition.

Common symptoms of Clouston syndrome include nail dystrophy, which means the nails are not formed normally, alopecia (hair loss), and palmoplantar hyperkeratosis, which is thickening of the skin on the palms and soles. These features form the clinical triad that defines the condition.

Clouston syndrome is caused by changes in a gene called GJB6. The condition is inherited in an autosomal dominant manner, meaning that a change in just one copy of the gene can lead to the features of the syndrome.

Information about treatment is currently limited for this condition.

Information about prognosis is currently limited for this condition.

Information about current research and future directions is currently limited for this condition.