Common variable immunodeficiency (CVID) comprises a heterogeneous group of diseases characterized by a significant hypogammaglobulinemia of unknown cause, failure to produce specific antibodies after ...
Comprehensive, easy-to-understand information about this condition
How we create this content →The documentation surrounding common variable immunodeficiency is limited due to its heterogeneous nature and the relatively low prevalence of the condition, which makes large-scale clinical studies challenging. Additionally, the genetic basis of CVID is complex and still being characterized, contributing to the variability in clinical presentation and treatment response among affected individuals.
To navigate your care effectively, seek a specialist in immunology, particularly one with expertise in primary immunodeficiencies. Consider participating in clinical trials, as they may provide access to new therapies and comprehensive care. While no specific patient organizations are identified for CVID, resources like the Genetic and Rare Diseases Information Center (GARD) at rarediseases.info.nih.gov can provide valuable information. Genetic counseling may also be beneficial to discuss potential hereditary implications and family planning.
There are currently 22 active clinical trials focusing on common variable immunodeficiency, indicating ongoing research efforts to better understand and treat this condition. Notable orphan drugs in development include IgA extracted from human milk and Leniolisib. For more information on these trials, you can visit ClinicalTrials.gov and search for common variable immunodeficiency: https://clinicaltrials.gov/search?cond=common%20variable%20immunodeficiency.
Actionable guidance for navigating care for common variable immunodeficiency
To navigate your care effectively, seek a specialist in immunology, particularly one with expertise in primary immunodeficiencies. Consider participating in clinical trials, as they may provide access to new therapies and comprehensive care. While no specific patient organizations are identified for CVID, resources like the Genetic and Rare Diseases Information Center (GARD) at rarediseases.info.nih.gov can provide valuable information. Genetic counseling may also be beneficial to discuss potential hereditary implications and family planning.
Consider asking your healthcare providers these condition-specific questions
Helpful links for rare disease information and support
The documentation surrounding common variable immunodeficiency is limited due to its heterogeneous nature and the relatively low prevalence of the condition, which makes large-scale clinical studies challenging. Additionally, the genetic basis of CVID is complex and still being characterized, contributing to the variability in clinical presentation and treatment response among affected individuals.
To navigate your care effectively, seek a specialist in immunology, particularly one with expertise in primary immunodeficiencies. Consider participating in clinical trials, as they may provide access to new therapies and comprehensive care. While no specific patient organizations are identified for CVID, resources like the Genetic and Rare Diseases Information Center (GARD) at rarediseases.info.nih.gov can provide valuable information. Genetic counseling may also be beneficial to discuss potential hereditary implications and family planning.
There are currently 22 active clinical trials focusing on common variable immunodeficiency, indicating ongoing research efforts to better understand and treat this condition. Notable orphan drugs in development include IgA extracted from human milk and Leniolisib. For more information on these trials, you can visit ClinicalTrials.gov and search for common variable immunodeficiency: https://clinicaltrials.gov/search?cond=common%20variable%20immunodeficiency.
Actionable guidance for navigating care for common variable immunodeficiency
To navigate your care effectively, seek a specialist in immunology, particularly one with expertise in primary immunodeficiencies. Consider participating in clinical trials, as they may provide access to new therapies and comprehensive care. While no specific patient organizations are identified for CVID, resources like the Genetic and Rare Diseases Information Center (GARD) at rarediseases.info.nih.gov can provide valuable information. Genetic counseling may also be beneficial to discuss potential hereditary implications and family planning.
Consider asking your healthcare providers these condition-specific questions
Helpful links for rare disease information and support
The documentation surrounding common variable immunodeficiency is limited due to its heterogeneous nature and the relatively low prevalence of the condition, which makes large-scale clinical studies challenging. Additionally, the genetic basis of CVID is complex and still being characterized, contributing to the variability in clinical presentation and treatment response among affected individuals.
To navigate your care effectively, seek a specialist in immunology, particularly one with expertise in primary immunodeficiencies. Consider participating in clinical trials, as they may provide access to new therapies and comprehensive care. While no specific patient organizations are identified for CVID, resources like the Genetic and Rare Diseases Information Center (GARD) at rarediseases.info.nih.gov can provide valuable information. Genetic counseling may also be beneficial to discuss potential hereditary implications and family planning.
There are currently 22 active clinical trials focusing on common variable immunodeficiency, indicating ongoing research efforts to better understand and treat this condition. Notable orphan drugs in development include IgA extracted from human milk and Leniolisib. For more information on these trials, you can visit ClinicalTrials.gov and search for common variable immunodeficiency: https://clinicaltrials.gov/search?cond=common%20variable%20immunodeficiency.
Actionable guidance for navigating care for common variable immunodeficiency
To navigate your care effectively, seek a specialist in immunology, particularly one with expertise in primary immunodeficiencies. Consider participating in clinical trials, as they may provide access to new therapies and comprehensive care. While no specific patient organizations are identified for CVID, resources like the Genetic and Rare Diseases Information Center (GARD) at rarediseases.info.nih.gov can provide valuable information. Genetic counseling may also be beneficial to discuss potential hereditary implications and family planning.
Consider asking your healthcare providers these condition-specific questions
Helpful links for rare disease information and support
Research studies investigating treatments and therapies for this condition.
Active Trials
Total Trials
Data from ClinicalTrials.gov Jan 30, 2026
Consider asking your healthcare providers these condition-specific questions
European rare disease database
Genetic and Rare Diseases Info Center
AI-Generated Content: This summary was generated using AI. Content has been fact-checked. Always consult with qualified healthcare providers for medical guidance.
Organizations with approved therapies for this disease
No approved therapies yet
Research is ongoing — 4 companies have orphan drug designations for this disease
Kisho delivers this disease record via API, including phenotypes (HPO), genes, orphan drug designations, screening status, and PAG mapping, with version history and governance.