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common variable immunodeficiency (CVID) - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

common variable immunodeficiency

MONDO:0015517

Also known as:CVIDCommon Variable Immune Deficiencycommon variable agammaglobulinemia

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Overview

Common variable immunodeficiency (CVID) comprises a heterogeneous group of diseases characterized by a significant hypogammaglobulinemia of unknown cause, failure to produce specific antibodies after immunizations and susceptibility to bacterial infections, predominantly caused by encapsulated bacteria.

OnsetCHILDHOOD

TreatmentsNo approved treatments · 4 in pipeline

Clinical Trials18 registered · 9 recruiting

Diagnosis

Biomarker and diagnostic research for common variable immunodeficiency has been reported in the published literature.

Treatment

Compiled from FDA-approved drug records, orphan drug designations, and FDA Adverse Event Reporting System (FAERS) safety data. GeneReviews management guidance is included where available.

No approved treatments are currently available for common variable immunodeficiency. An additional 4 compounds hold orphan drug designation.

Orphan Drug Designations

While no drugs are FDA-approved specifically for common variable immunodeficiency, some of the following designated compounds may be used off-label in clinical practice. Treatment decisions should be made in consultation with a specialist familiar with this condition.

The following drugs have received orphan drug designation from the FDA for common variable immunodeficiency. Orphan designation reflects regulatory interest and does not indicate approval for treatment.

Brand Name	Generic Name	Sponsor

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

18 clinical trials registered, 9 recruiting. Interventions under study include drug therapy, other interventions, procedural interventions, and biologic therapy. Pipeline includes 1 PHASE4, 10 PHASE2, 1 PHASE1. Research is sponsored by a mix of industry and academic institutions.

NCT ID	Title	Phase	Sponsor	Status
[NCT04339777](https://clinicaltrials.gov/study/NCT04339777)

Data assembled from 5 of 12 sources · Last updated Sep 18, 2026, 12:38 AM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:1572

GARD

Genetic and Rare Diseases Info Center

GARD:6140

Questions for Your Care Team

→Are any of the 18 active clinical trials a good fit for my situation?
→With 4 compounds in the orphan drug pipeline, which are furthest along in development and which clinical trials should I be aware of?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

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Research Type	Count	% of Total
Research summaries	46	26%
Laboratory research	39	22%
Disease patterns and progression	36	20%
Patient case studies	34	19%
Testing and diagnosis research	11	6%
Clinical study results	7	4%
Other research	3	2%
New treatment approaches	3	2%

common variable immunodeficiency

Overview

Diagnosis

Treatment

Orphan Drug Designations

Research Landscape

Medical References

External Resources

Orphanet

GARD

Subtypes

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Clinical Trials

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