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congenital smooth muscle hamartoma - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

congenital smooth muscle hamartoma

MONDO:0016986

Overview

Congenital smooth muscle hamartoma (CSMH) is a rare cutaneous hamartomatous lesion most often located on the lumbosacral area or proximal limbs (but rarely on atypical areas such as scalp, eyelid or foot) and characterized by a disorganized proliferation of smooth muscle fibers of arrector pili presenting usually as a localized skin-colored or hyperpigmented plaque (up to 10 cm in diameter) with prominent vellus hairs (most common classic form) or less commonly by multiple skin-colored papules that can coalesce to form irregularly shaped plaques. With time, hyperpigmentation and vellus hairs usually diminish and neither malignant transformation nor associated systemic involvement has been reported.

ResearchLimited published research (4 articles)

Prognosis

Estimated prevalence: Unknown (Unknown prevalence).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for congenital smooth muscle hamartoma.

5 publications have been identified in PubMed for congenital smooth muscle hamartoma. Research spans Case Report / Case Series (100%).

Recent Publications

Croix M (2026). [PMID: 41645685](https://pubmed.ncbi.nlm.nih.gov/41645685/). *Dermatol Reports*. [Case Report / Case Series]
Colmant C (2026). [PMID: 41669896](https://pubmed.ncbi.nlm.nih.gov/41669896/). *Pediatr Dermatol*. [Case Report / Case Series]
Meza V (2025). [PMID: 39692078](https://pubmed.ncbi.nlm.nih.gov/39692078/). *J Ultrasound Med*. [Case Report / Case Series]
Pal SS (2024). [PMID: 39391140](https://pubmed.ncbi.nlm.nih.gov/39391140/). *Int J Clin Pediatr Dent*. [Case Report / Case Series]

Data assembled from 3 of 12 sources · Last updated Sep 20, 2026, 5:50 AM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:263435

GARD

Genetic and Rare Diseases Info Center

GARD:20902

Questions for Your Care Team

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congenital smooth muscle hamartoma

Overview

Prognosis

Research Landscape

Recent Publications

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team