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Cranio-osteoarthropathy (COA) is a form of primary hypertrophic osteoarthropathy characterized by delayed closure of the cranial sutures and fontanels, digital clubbing, arthropathy, and periostosis.
Features include very common findings: Large fontanelles, Abnormal skull morphology, Mottled pigmentation, and Abnormal cortical bone morphology; and common findings: Joint inflammation (arthritis), Joint swelling, Joint stiffness, and Joint wear and tear (osteoarthritis) and others. 14 total HPO annotations.
Organ System | Phenotype Count | Example Features |
|---|---|---|
Bones and joints | 6 | Joint inflammation (arthritis), Joint swelling, Joint stiffness |
Biomarker and diagnostic research for cranio-osteoarthropathy has been reported in the published literature.
Phenotype severity distribution: 4 very common features, 8 common features.
Estimated prevalence: <1 in 1,000,000 (VERY_RARE).
No clinical trials have been registered for cranio-osteoarthropathy.
150 publications have been identified in PubMed for cranio-osteoarthropathy. Research spans Review / Meta-Analysis (52%), Case Report / Case Series (23%), and Basic Science / Preclinical (13%).
Research Type | Count | % of Total |
|---|---|---|
Research summaries | 78 | 52% |
Data assembled from 4 of 12 sources · Last updated Sep 20, 2026, 1:00 AM UTC
European rare disease database
Genetic and Rare Diseases Info Center
Arms and legs | 2 | Deviation of finger, Clubbing of toes |
Skin | 1 | Eczematoid dermatitis |
34 |
23% |
Laboratory research | 19 | 13% |
Disease patterns and progression | 10 | 7% |
Other research | 5 | 3% |
New treatment approaches | 2 | 1% |
Testing and diagnosis research | 1 | 1% |
Clinical study results | 1 | 1% |
Stoian M (2026). [PMID: 41682637](https://pubmed.ncbi.nlm.nih.gov/41682637/). *J Clin Med*. [Case Report / Case Series]
Anderson EN (2026). [PMID: 41468891](https://pubmed.ncbi.nlm.nih.gov/41468891/). *Am J Hum Genet*. [Gene Therapy / Novel Therapeutics]
Amado C (2026). [PMID: 40975490](https://pubmed.ncbi.nlm.nih.gov/40975490/). *Ann Allergy Asthma Immunol*. [Review / Meta-Analysis]
Inoue F (2026). [PMID: 42173542](https://pubmed.ncbi.nlm.nih.gov/42173542/). *BMJ Case Rep*. [Case Report / Case Series]
Al Zahra F (2026). [PMID: 41552801](https://pubmed.ncbi.nlm.nih.gov/41552801/). *J Surg Case Rep*. [Case Report / Case Series]
Staunton MK (2026). [PMID: 42011393](https://pubmed.ncbi.nlm.nih.gov/42011393/). *JAAD Case Rep*. [Case Report / Case Series]
Ng YT (2026). [PMID: 42230008](https://pubmed.ncbi.nlm.nih.gov/42230008/). *BMJ Case Rep*. [Case Report / Case Series]
Magazin M (2026). [PMID: 41718423](https://pubmed.ncbi.nlm.nih.gov/41718423/). *Orbit*. [Review / Meta-Analysis]
Cajiao K (2026). [PMID: 41865604](https://pubmed.ncbi.nlm.nih.gov/41865604/). *Clinics (Sao Paulo)*. [Basic Science / Preclinical]
Gupta P (2026). [PMID: 41522567](https://pubmed.ncbi.nlm.nih.gov/41522567/). *Indian J Hematol Blood Transfus*. [Case Report / Case Series]