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crossed polysyndactyly - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

crossed polysyndactyly

MONDO:0008286

Also known as:crossed polydactylypolysyndactyly, crossed

Overview

Crossed polysyndactyly is a rare, genetic, congenital limb malformation disorder characterized by unilateral or bilateral postaxial polydactyly in the hands and preaxial polydactyly in the feet, associated with bilateral cutaneous syndactyly of first, second and third toes. Cutaneous syndactyly in hands has also been reported in some patients. There have been no further descriptions in the literature since 1994.

Prognosis

Estimated prevalence: <1 in 1,000,000 (VERY_RARE).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for crossed polysyndactyly.

15 publications have been identified in PubMed for crossed polysyndactyly. Research spans Clinical Trial Publication (33%), Epidemiology / Natural History (27%), and Basic Science / Preclinical (20%).

Research Type	Count	% of Total
Clinical study results	5	33%

Data assembled from 4 of 12 sources · Last updated Sep 18, 2026, 1:32 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

OMIM

Online Mendelian Inheritance in Man

OMIM:175690

Orphanet

European rare disease database

Orphanet:2935

GARD

Genetic and Rare Diseases Info Center

GARD:1617

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crossed polysyndactyly

Overview

Prognosis

Research Landscape

Medical References

External Resources

OMIM

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

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