PLA2G4A function has not been fully characterized.

Cytosolic phospholipase-A2 alpha deficiency associated bleeding disorder has been associated with mutations in the PLA2G4A gene on chromosome 1.

Genetic testing for PLA2G4A is available. Testing is considered supportive for diagnosis.

Estimated prevalence: <1 in 1,000,000 (VERY_RARE).

No clinical trials have been registered for cytosolic phospholipase-A2 alpha deficiency associated bleeding disorder.

107 publications have been identified in PubMed for cytosolic phospholipase-A2 alpha deficiency associated bleeding disorder. Kisho has analyzed 28 by research type. Research spans Review / Meta-Analysis (68%), Basic Science / Preclinical (29%), and Gene Therapy / Novel Therapeutics (4%).

Recent Publications

• Kusch C (2026). [PMID: 41570126](https://pubmed.ncbi.nlm.nih.gov/41570126/). *Science*. [Basic Science / Preclinical]

• Braune S (2025). [PMID: 40086861](https://pubmed.ncbi.nlm.nih.gov/40086861/). *Dtsch Med Wochenschr*. [Review / Meta-Analysis]

• Kaiser R (2025). [PMID: 40906924](https://pubmed.ncbi.nlm.nih.gov/40906924/). *Blood*. [Review / Meta-Analysis]

• Wu Y (2025). [PMID: 41345945](https://pubmed.ncbi.nlm.nih.gov/41345945/). *J Neuroinflammation*. [Basic Science / Preclinical]

• Capogrosso P (2025). [PMID: 40393866](https://pubmed.ncbi.nlm.nih.gov/40393866/). *Eur Urol*. [Review / Meta-Analysis]

• Carvalho E (2025). [PMID: 40525760](https://pubmed.ncbi.nlm.nih.gov/40525760/). *Eur J Clin Invest*. [Basic Science / Preclinical]

• Li C (2025). [PMID: 40710328](https://pubmed.ncbi.nlm.nih.gov/40710328/). *Cells*. [Review / Meta-Analysis]

• Rajput S (2025). [PMID: 39159826](https://pubmed.ncbi.nlm.nih.gov/39159826/). *Ann Pharm Fr*. [Review / Meta-Analysis]

• Hasan S (2025). [PMID: 40605975](https://pubmed.ncbi.nlm.nih.gov/40605975/). *Genes Dis*. [Gene Therapy / Novel Therapeutics]

• Rodríguez-Alén A (2025). [PMID: 41301446](https://pubmed.ncbi.nlm.nih.gov/41301446/). *Biomolecules*. [Review / Meta-Analysis]