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dense deposit disease - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

dense deposit disease

MONDO:0019736

Also known as:Mesangiocapillary glomerulonephritis type 2membranoproliferative glomerulonephritis type 2MPGN 2

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Overview

Dense deposit disease, a histological subtype of MPGN is an idiopathic chronic progressive kidney disorder distinguished by the presence of intra-membranous dense deposits in addition to immune complex subendothelial deposits in the glomerular capillary walls. This form often has a higher recurrence rate after a kidney transplant and is associated with extra-renal manifestations such as familial drusen.

Clinical Trials4 registered · 2 recruiting

Diagnosis

Biomarker and diagnostic research for dense deposit disease has been reported in the published literature.

Prognosis

Estimated prevalence: 1-9 in 1,000,000 (Rare).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

4 clinical trials registered, 2 recruiting. Interventions under study include drug therapy and other interventions. Pipeline includes 1 PHASE3, 2 PHASE2. Research is sponsored by a mix of industry and academic institutions.

48 publications have been identified in PubMed for dense deposit disease. Research spans Case Report / Case Series (38%), Review / Meta-Analysis (17%), and Epidemiology / Natural History (17%).

Research Type	Count	% of Total
Patient case studies	18

Data assembled from 4 of 12 sources · Last updated Sep 18, 2026, 11:05 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:93571

GARD

Genetic and Rare Diseases Info Center

GARD:8555

Questions for Your Care Team

→Are any of the 4 active clinical trials a good fit for my situation?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

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dense deposit disease

Overview

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

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