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This syndrome is characterized by diarrhea and vomiting after ingestion of trehalose, a disaccharide found mainly in mushrooms.
Features include: Diarrhea and Abdominal pain.
Organ System | Phenotype Count | Example Features |
|---|---|---|
Digestive system | 2 | Diarrhea, Abdominal pain |
TREH function has not been fully characterized.
Diarrhea-vomiting due to trehalase deficiency is associated with mutations in the TREH gene on chromosome 11.
Genetic testing for TREH is available. Testing is considered confirmatory for diagnosis.
Estimated prevalence: Unknown (Unknown prevalence).
No clinical trials have been registered for diarrhea-vomiting due to trehalase deficiency.
1 publication has been identified in PubMed for diarrhea-vomiting due to trehalase deficiency. Research spans Epidemiology / Natural History (100%).
Kozlov AI (2024). [PMID: 39283558](https://pubmed.ncbi.nlm.nih.gov/39283558/). *Doklady. Biochemistry and biophysics*. [Epidemiology / Natural History]
Data assembled from 6 of 12 sources · Last updated Sep 20, 2026, 6:03 PM UTC
Online Mendelian Inheritance in Man
European rare disease database
Genetic and Rare Diseases Info Center