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This syndrome is characterized by the association of ankylosing vertebral hyperostosis with hyperkeratosis of the soles and palms.
Biomarker and diagnostic research for diffuse idiopathic skeletal hyperostosis has been reported in the published literature.
Estimated prevalence: <1 in 1,000,000 (VERY_RARE).
No clinical trials have been registered for diffuse idiopathic skeletal hyperostosis.
175 publications have been identified in PubMed for diffuse idiopathic skeletal hyperostosis. Research spans Case Report / Case Series (35%), Epidemiology / Natural History (25%), and Basic Science / Preclinical (14%).
Research Type | Count | % of Total |
|---|---|---|
Patient case studies | 62 | 35% |
Data assembled from 3 of 12 sources · Last updated Sep 18, 2026, 7:13 PM UTC
European rare disease database
Genetic and Rare Diseases Info Center
Disease patterns and progression
44 |
25% |
Laboratory research | 24 | 14% |
Research summaries | 15 | 9% |
Clinical study results | 14 | 8% |
Testing and diagnosis research | 10 | 6% |
Other research | 6 | 3% |
Kiefer D (2026). [PMID: 41963077](https://pubmed.ncbi.nlm.nih.gov/41963077/). *RMD Open*. [Epidemiology / Natural History]
Luo TD (2026). [PMID: 30855792](https://pubmed.ncbi.nlm.nih.gov/30855792/). *Unknown Journal*. [Other]
Fada L (2026). [PMID: 41658681](https://pubmed.ncbi.nlm.nih.gov/41658681/). *Cureus*. [Diagnostic / Biomarker]
Jain H (2026). [PMID: 41659844](https://pubmed.ncbi.nlm.nih.gov/41659844/). *Neurosurg Pract*. [Case Report / Case Series]
Librianto D (2026). [PMID: 42130534](https://pubmed.ncbi.nlm.nih.gov/42130534/). *Int J Surg Case Rep*. [Case Report / Case Series]
Golubovsky JL (2026). [PMID: 42139724](https://pubmed.ncbi.nlm.nih.gov/42139724/). *J Neurosurg Spine*. [Epidemiology / Natural History]
Ji W (2026). [PMID: 41782748](https://pubmed.ncbi.nlm.nih.gov/41782748/). *Frontiers in endocrinology*. [Basic Science / Preclinical]
Gohara D (2026). [PMID: 41737098](https://pubmed.ncbi.nlm.nih.gov/41737098/). *Cureus*. [Case Report / Case Series]
Sekine C (2026). [PMID: 42225319](https://pubmed.ncbi.nlm.nih.gov/42225319/). *BMJ Case Rep*. [Case Report / Case Series]
Tamatani I (2026). [PMID: 42005109](https://pubmed.ncbi.nlm.nih.gov/42005109/). *Cureus*. [Case Report / Case Series]