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Estimated prevalence: Unknown (Unknown prevalence).
No clinical trials have been registered for diffuse palmoplantar keratoderma with painful fissures.
4 publications have been identified in PubMed for diffuse palmoplantar keratoderma with painful fissures. Research spans Case Report / Case Series (75%) and Basic Science / Preclinical (25%).
Du Y (2026). [PMID: 41885793](https://pubmed.ncbi.nlm.nih.gov/41885793/). *Acta Derm Venereol*. [Case Report / Case Series]
Premkumar L (2025). [PMID: 41613660](https://pubmed.ncbi.nlm.nih.gov/41613660/). *Cureus*. [Case Report / Case Series]
Ye J (2025). [PMID: 40765698](https://pubmed.ncbi.nlm.nih.gov/40765698/). *Clinical, cosmetic and investigational dermatology*. [Case Report / Case Series]
Weinberg RL (2024). [PMID: 38866482](https://pubmed.ncbi.nlm.nih.gov/38866482/). *The Journal of neuroscience : the official journal of the Society for Neuroscience*. [Basic Science / Preclinical]
Data assembled from 3 of 12 sources · Last updated Sep 20, 2026, 8:41 AM UTC
European rare disease database
Genetic and Rare Diseases Info Center