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diprosopus - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

diprosopus

MONDO:0015672

Also known as:Diprosopiacraniofacial duplication

Overview

Diprosopus is a rare, life-threatening developmental defect during embryogenesis, and a subtype of conjoined twins, characterized by partial or complete duplication of the facial structures on a single head, neck, trunk and body. It may be associated with congenital anomalies involving the central nervous, cardiovascular, gastrointestinal and respiratory systems. Cleft lip and palate have been reported in rare cases.

ResearchLimited published research (8 articles)

Prognosis

Estimated prevalence: <1 in 1,000,000 (VERY_RARE).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for diprosopus.

8 publications have been identified in PubMed for diprosopus. Research spans Case Report / Case Series (75%), Review / Meta-Analysis (13%), and Basic Science / Preclinical (13%).

Recent Publications

Yefter ET (2026). [PMID: 41815445](https://pubmed.ncbi.nlm.nih.gov/41815445/). *International journal of surgery case reports*. [Case Report / Case Series]
Albarella S (2026). [PMID: 41793988](https://pubmed.ncbi.nlm.nih.gov/41793988/). *Journal of comparative pathology*. [Basic Science / Preclinical]
Li CX (2026). [PMID: 41540721](https://pubmed.ncbi.nlm.nih.gov/41540721/). *Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology*. [Case Report / Case Series]
Zhou Q (2025). [PMID: 39833719](https://pubmed.ncbi.nlm.nih.gov/39833719/). *BMC pregnancy and childbirth*. [Review / Meta-Analysis]
Pontes MTVM (2024). [PMID: 38439051](https://pubmed.ncbi.nlm.nih.gov/38439051/). *Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry*. [Case Report / Case Series]

Data assembled from 3 of 12 sources · Last updated Sep 18, 2026, 8:08 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:1681

GARD

Genetic and Rare Diseases Info Center

GARD:1876

Questions for Your Care Team

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diprosopus

Overview

Prognosis

Research Landscape

Recent Publications

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team