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distal arthrogryposis type 10 (DA10) - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

distal arthrogryposis type 10

MONDO:0016675

Also known as:DA10plantar flexion contractureshort Achilles tendon

Overview

GeneticsAutosomal dominant

ResearchLimited published research (7 articles)

Clinical Presentation

Built from Human Phenotype Ontology (HPO) phenotype annotations and GeneReviews clinical descriptions. Features represent findings documented across known cases — not an exhaustive list of possible symptoms.

Features include always present findings: Distal arthrogryposis, Plantar flexion contracture, and Tip-toe gait. 9 total HPO annotations.

Organ System	Phenotype Count	Example Features
Muscles	5	Hamstring contractures, Distal arthrogryposis, Plantar flexion contracture

Diagnosis

Biomarker and diagnostic research for distal arthrogryposis type 10 has been reported in the published literature.

Prognosis

Phenotype severity distribution: 3 always present features.

Estimated prevalence: <1 in 1,000,000 (VERY_RARE).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for distal arthrogryposis type 10.

7 publications have been identified in PubMed for distal arthrogryposis type 10. Research spans Case Report / Case Series (43%), Diagnostic / Biomarker (14%), and Review / Meta-Analysis (14%).

Recent Publications

Meller LLT (2026). [PMID: 41499205](https://pubmed.ncbi.nlm.nih.gov/41499205/). *Endocrinol Diabetes Metab Case Rep*. [Case Report / Case Series]
Geusebroek G (2026). [PMID: 42178751](https://pubmed.ncbi.nlm.nih.gov/42178751/). *J Orthop Res*. [Basic Science / Preclinical]
Velardo D (2026). [PMID: 42211024](https://pubmed.ncbi.nlm.nih.gov/42211024/). *Front Genet*. [Case Report / Case Series]
Abdel-Hamid MS (2025). [PMID: 39966089](https://pubmed.ncbi.nlm.nih.gov/39966089/). *Clin Genet*. [Diagnostic / Biomarker]
Johnson T (2024). [PMID: 39559612](https://pubmed.ncbi.nlm.nih.gov/39559612/). *Cureus*. [Case Report / Case Series]

Data assembled from 5 of 12 sources · Last updated Sep 19, 2026, 11:54 AM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

OMIM

Online Mendelian Inheritance in Man

OMIM:187370

Orphanet

European rare disease database

Orphanet:251515

GARD

Genetic and Rare Diseases Info Center

GARD:17212

Questions for Your Care Team

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distal arthrogryposis type 10

Overview

Clinical Presentation

Diagnosis

Prognosis

Research Landscape

Recent Publications

Medical References

External Resources

OMIM

Orphanet

GARD

Related Diseases

Questions for Your Care Team

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