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distal monosomy 10p - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

distal monosomy 10p

MONDO:0011055

Also known as:distal 10p deletiondistal monosomy type 10pmonosomy 10pter

Overview

Distal monosomy 10p is a rare chromosomal disorder in which the tip of the short arm (p arm) of chromosome 10 is deleted resulting in a variable phenotype depending on the size of the deletion. The deletion may involve only the terminal 10p15 band, or extend towards the centromere to bands 10p14 or 10p13.

ResearchLimited published research (1 article)

Clinical Presentation

Built from Human Phenotype Ontology (HPO) phenotype annotations and GeneReviews clinical descriptions. Features represent findings documented across known cases — not an exhaustive list of possible symptoms.

Features include very common findings: Cryptorchidism, Wide nasal bridge, Convex nasal ridge, and Intellectual disability and others; and common findings: Microcephaly, Hypertelorism, Micrognathia, and Hearing abnormality and others. 31 total HPO annotations.

Organ System	Phenotype Count	Example Features
Head and neck	3	Microcephaly, Cleft palate, Non-midline cleft of the upper lip

Prognosis

Phenotype severity distribution: 5 very common features, 16 common features.

Estimated prevalence: <1 in 1,000,000 (VERY_RARE).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for distal monosomy 10p.

1 publication has been identified in PubMed for distal monosomy 10p. Research spans Review / Meta-Analysis (100%).

Recent Publications

Bonati MT (2024). [PMID: 38927613](https://pubmed.ncbi.nlm.nih.gov/38927613/). *Genes (Basel)*. [Review / Meta-Analysis]

Data assembled from 4 of 12 sources · Last updated Sep 18, 2026, 7:38 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:1580

GARD

Genetic and Rare Diseases Info Center

GARD:1323

Questions for Your Care Team

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distal monosomy 10p

Overview

Clinical Presentation

Prognosis

Research Landscape

Recent Publications

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

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