Kisho is an information platform, not a medical provider. Nothing on this site constitutes medical advice, diagnosis, or treatment recommendations. All content is aggregated from publicly available sources (including ClinicalTrials.gov, PubMed, FDA.gov, and Orphanet) and is provided for informational purposes only. Clinical trial eligibility, treatment decisions, and any health-related actions should always be discussed with a qualified healthcare professional. Kisho does not endorse any specific therapy, organization, or clinical trial. Terms of use · Privacy policy
Welander distal myopathy (WDM) is a distal myopathy, characterized by weakness in the distal upper extremities, usually finger and wrist extensors which later progresses to all hand muscles and distal lower extremity, primarily in toe and ankle extensors.
Features include: Steppage gait, Distal amyotrophy, Distal muscle weakness, and Rimmed vacuoles and 1 more.
Organ System | Phenotype Count | Example Features |
|---|---|---|
Brain and nerves | 1 | Steppage gait |
Muscles |
TIA1 function has not been fully characterized.
Distal myopathy, Welander type is associated with mutations in the TIA1 gene on chromosome 2.
Genetic testing for TIA1 is available. Testing is considered confirmatory for diagnosis.
Estimated prevalence: Unknown (Unknown prevalence).
No clinical trials have been registered for distal myopathy, Welander type.
40 publications have been identified in PubMed for distal myopathy, Welander type. Research spans Basic Science / Preclinical (40%), Case Report / Case Series (23%), and Review / Meta-Analysis (13%).
Research Type | Count | % of Total |
|---|---|---|
Laboratory research | 16 | 40% |
Data assembled from 6 of 12 sources · Last updated Sep 20, 2026, 5:42 AM UTC
Online Mendelian Inheritance in Man
European rare disease database
Genetic and Rare Diseases Info Center
Distal muscle weakness |
Lab test results | 1 | Mildly elevated creatine kinase |
Patient case studies
9 |
23% |
Research summaries | 5 | 13% |
Disease patterns and progression | 5 | 13% |
New treatment approaches | 3 | 8% |
Clinical study results | 2 | 5% |
Jay CM (2026). [PMID: 42186366](https://pubmed.ncbi.nlm.nih.gov/42186366/). *J Gene Med*. [Basic Science / Preclinical]
Kim DW (2026). [PMID: 41963465](https://pubmed.ncbi.nlm.nih.gov/41963465/). *Exp Mol Med*. [Basic Science / Preclinical]
Boonsri P (2026). [PMID: 41575995](https://pubmed.ncbi.nlm.nih.gov/41575995/). *PloS one*. [Gene Therapy / Novel Therapeutics]
Zhao T (2026). [PMID: 41786146](https://pubmed.ncbi.nlm.nih.gov/41786146/). *The Journal of biological chemistry*. [Basic Science / Preclinical]
Suzuki N (2026). [PMID: 41093591](https://pubmed.ncbi.nlm.nih.gov/41093591/). *Tohoku J Exp Med*. [Case Report / Case Series]
Zhou W (2026). [PMID: 41951012](https://pubmed.ncbi.nlm.nih.gov/41951012/). *Biochim Biophys Acta Mol Basis Dis*. [Review / Meta-Analysis]
Ramos Velasco B (2025). [PMID: 40735695](https://pubmed.ncbi.nlm.nih.gov/40735695/). *Genes & diseases*. [Basic Science / Preclinical]
Deng J (2025). [PMID: 41239392](https://pubmed.ncbi.nlm.nih.gov/41239392/). *BMC musculoskeletal disorders*. [Case Report / Case Series]
Singh S (2025). [PMID: 41339784](https://pubmed.ncbi.nlm.nih.gov/41339784/). *Molecular medicine (Cambridge, Mass.)*. [Case Report / Case Series]
Costa AF (2025). [PMID: 41331965](https://pubmed.ncbi.nlm.nih.gov/41331965/). *Journal of clinical neuromuscular disease*. [Gene Therapy / Novel Therapeutics]
AI-curated news mentioning distal myopathy, Welander type
Updated Jul 21, 2026
A recent publication provides an updated overview of Welander distal myopathy, detailing its clinical features and genetic underpinnings. This research enhances understanding of distal myopathies, which can inform future therapeutic strategies.