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drug rash with eosinophilia and systemic symptoms (DHS) - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

drug rash with eosinophilia and systemic symptoms

MONDO:0015340

Also known as:DHSDRESSDRESS syndrome

Find Clinical TrialsTrials

Overview

DRESS syndrome (Drug Rash with Eosinophilia and Systemic Symptoms) is a hypersensitivity reaction characterized by a generalized skin rash, fever, eosinophilia, lymphocytosis and visceral involvement (hepatitis, nephritis, pneumonitis, pericarditis and myocarditis) and, in some patients, reactivation of human herpes virus 6.

Clinical Trials3 registered

Patient Orgs1 organizations · DRESS Syndrome Foundation

Diagnosis

Biomarker and diagnostic research for drug rash with eosinophilia and systemic symptoms has been reported in the published literature.

Prognosis

Estimated prevalence: Unknown (Unknown prevalence).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

3 clinical trials registered. Interventions under study include drug therapy and other interventions. Pipeline includes 1 PHASE2, 1 EARLY_PHASE1. Research is primarily sponsored by academic and government institutions.

224 publications have been identified in PubMed for drug rash with eosinophilia and systemic symptoms. Kisho has analyzed 134 by research type. Research spans Case Report / Case Series (49%), Review / Meta-Analysis (25%), and Epidemiology / Natural History (9%).

Research Type	Count	% of Total
Patient case studies	66

Data assembled from 4 of 12 sources · Last updated Sep 19, 2026, 5:47 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Patient Support

Patient Advocacy Groups

View all PAGs →

DRESS Syndrome FoundationPrimary Focus

USWebsite ↗

Patient Advocacy Groups (PAGs) provide support, resources, and community for patients and caregivers.

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Medical References

External Resources

Orphanet

European rare disease database

Orphanet:139402

GARD

Genetic and Rare Diseases Info Center

GARD:13629

Questions for Your Care Team

→Are any of the 3 active clinical trials a good fit for my situation?
→Are there specialists or centers of excellence for this condition in my area?
→How can I connect with DRESS Syndrome Foundation and other patient organizations for support?

← Back to All Diseases

Kisho

drug rash with eosinophilia and systemic symptoms

Overview

Diagnosis

Prognosis

Research Landscape

Patient Support

Patient Advocacy Groups

Medical References

External Resources

Orphanet

GARD

Questions for Your Care Team

Questions for Your Care Team

Recent Publications

Latest News & Developments

Granulomatous Interstitial Nephritis With Perivascular Involvement in Carbamazepine-Induced DRESS Syndrome: A Case Report.

Management and predictors of ICU admission in DRESS: A multicentre retrospective cohort study.

Allopurinol-associated Drug Reaction with Eosinophilia and Systemic Symptom Syndrome: A Severe Delayed Drug Hypersensitivity Reaction.

drug rash with eosinophilia and systemic symptoms

Overview

Diagnosis

Prognosis

Research Landscape

Patient Support

Patient Advocacy Groups

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Recent Publications

Latest News & Developments

Granulomatous Interstitial Nephritis With Perivascular Involvement in Carbamazepine-Induced DRESS Syndrome: A Case Report.

Management and predictors of ICU admission in DRESS: A multicentre retrospective cohort study.

Allopurinol-associated Drug Reaction with Eosinophilia and Systemic Symptom Syndrome: A Severe Delayed Drug Hypersensitivity Reaction.