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Epibulbar lipodermoid B preauricular appendages B polythelia is a branchial arch syndrome described in seven sibs of one Danish family and characterized by supernumerary nipples (polythelia), preauricular appendages and often binocular epibulbar lipodermoids or unilateral subconjunctival lipodermoids.
Estimated prevalence: <1 in 1,000,000 (VERY_RARE).
No clinical trials have been registered for epibulbar lipodermoid-preauricular appendage-polythelia syndrome.
9 publications have been identified in PubMed for epibulbar lipodermoid-preauricular appendage-polythelia syndrome. Research spans Epidemiology / Natural History (44%), Case Report / Case Series (33%), and Basic Science / Preclinical (22%).
Potluri S (2026). [PMID: 41198137](https://pubmed.ncbi.nlm.nih.gov/41198137/). *Cornea*. [Basic Science / Preclinical]
Young A (2026). [PMID: 32809654](https://pubmed.ncbi.nlm.nih.gov/32809654/). *Unknown Journal*. [Epidemiology / Natural History]
Chamarthi VS (2026). [PMID: 35015423](https://pubmed.ncbi.nlm.nih.gov/35015423/). *Unknown Journal*. [Epidemiology / Natural History]
Fang F (2025). [PMID: 39934612](https://pubmed.ncbi.nlm.nih.gov/39934612/). *Ophthalmol Ther*. [Epidemiology / Natural History]
Anklesaria V (2025). [PMID: 39727250](https://pubmed.ncbi.nlm.nih.gov/39727250/). *Ophthalmic Plast Reconstr Surg*. [Epidemiology / Natural History]
Data assembled from 3 of 12 sources · Last updated Sep 20, 2026, 9:46 AM UTC
European rare disease database
Genetic and Rare Diseases Info Center
Somkuwar JK (2025). [PMID: 39956954](https://pubmed.ncbi.nlm.nih.gov/39956954/). *Spec Care Dentist*. [Case Report / Case Series]
Del Viso F (2025). [PMID: 39305124](https://pubmed.ncbi.nlm.nih.gov/39305124/). *Am J Med Genet A*. [Case Report / Case Series]
Singh P (2024). [PMID: 39309593](https://pubmed.ncbi.nlm.nih.gov/39309593/). *Med J Armed Forces India*. [Basic Science / Preclinical]
Singh A (2024). [PMID: 39317019](https://pubmed.ncbi.nlm.nih.gov/39317019/). *Int J Surg Case Rep*. [Case Report / Case Series]