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epilepsy with generalized tonic-clonic seizures (EGTCA) - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

epilepsy with generalized tonic-clonic seizures

MONDO:0005754

Also known as:EGTCAepilepsy with generalized tonic-clonic seizures aloneepileptic seizures, tonic-clonic

Find Clinical TrialsTrials

Overview

A generalized tonic-clonic seizure.

Treatments4 FDA approved

Clinical Trials1 registered · 1 recruiting

ResearchLimited published research (7 articles)

Diagnosis

Biomarker and diagnostic research for epilepsy with generalized tonic-clonic seizures has been reported in the published literature.

Treatment

Compiled from FDA-approved drug records, orphan drug designations, and FDA Adverse Event Reporting System (FAERS) safety data. GeneReviews management guidance is included where available.

1 FDA-approved treatment is available for epilepsy with generalized tonic-clonic seizures, including CARBAMAZEPINE (TEGRETOL XR, approved 1996).

Approved Therapies

Brand Name	Generic Name	Mechanism	Approved	Market Status

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

1 clinical trial registered, 1 recruiting. Interventions under study include drug therapy. Pipeline includes 1 PHASE2. Research is primarily sponsored by academic and government institutions.

7 publications have been identified in PubMed for epilepsy with generalized tonic-clonic seizures. Research spans Diagnostic / Biomarker (43%), Epidemiology / Natural History (29%), and Case Report / Case Series (14%).

Recent Publications

Zhang X (2025). [PMID: 39736142](https://pubmed.ncbi.nlm.nih.gov/39736142/). *Epilepsia open*. [Epidemiology / Natural History]
Sushkova OS (2025). [PMID: 40310354](https://pubmed.ncbi.nlm.nih.gov/40310354/). *Diagnostics (Basel, Switzerland)*. [Diagnostic / Biomarker]
Guan DM (2024). [PMID: 39319208](https://pubmed.ncbi.nlm.nih.gov/39319208/). *Pharmacogenomics and personalized medicine*. [Diagnostic / Biomarker]
Du Y (2024). [PMID: 39736645](https://pubmed.ncbi.nlm.nih.gov/39736645/). *BMC pregnancy and childbirth*. [Diagnostic / Biomarker]
Nanda P (2024). [PMID: 39052021](https://pubmed.ncbi.nlm.nih.gov/39052021/). *Epilepsia*. [Gene Therapy / Novel Therapeutics]

Data assembled from 4 of 12 sources · Last updated Sep 20, 2026, 10:55 AM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

Questions for Your Care Team

→What are the benefits and potential side effects of TEGRETOL XR for managing epilepsy with generalized tonic-clonic seizures?
→Are any of the 1 active clinical trial a good fit for my situation?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

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epilepsy with generalized tonic-clonic seizures

Overview

Diagnosis

Treatment

Approved Therapies

Research Landscape

Recent Publications

Medical References

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Clinical Trials