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An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the esophagus. It is characterized by the presence of malignant small cells.
Biomarker and diagnostic research for esophageal small cell neuroendocrine carcinoma has been reported in the published literature.
2 clinical trials registered, 1 recruiting. Interventions under study include drug therapy and procedural interventions. Pipeline includes 2 PHASE2. Research is primarily sponsored by academic and government institutions.
111 publications have been identified in PubMed for esophageal small cell neuroendocrine carcinoma. Research spans Case Report / Case Series (32%), Clinical Trial Publication (29%), and Basic Science / Preclinical (19%).
Research Type | Count | % of Total |
|---|---|---|
Patient case studies | 36 |
Data assembled from 3 of 12 sources · Last updated Sep 20, 2026, 5:51 AM UTC
Clinical study results | 32 | 29% |
Laboratory research | 21 | 19% |
Research summaries | 8 | 7% |
Disease patterns and progression | 8 | 7% |
Testing and diagnosis research | 3 | 3% |
New treatment approaches | 3 | 3% |
Zhang C (2026). [PMID: 41358271](https://pubmed.ncbi.nlm.nih.gov/41358271/). *Oncology letters*. [Basic Science / Preclinical]
Salunkhe R (2026). [PMID: 40912509](https://pubmed.ncbi.nlm.nih.gov/40912509/). *Int J Radiat Oncol Biol Phys*. [Clinical Trial Publication]
Monti S (2026). [PMID: 40752651](https://pubmed.ncbi.nlm.nih.gov/40752651/). *International journal of radiation oncology, biology, physics*. [Review / Meta-Analysis]
Diao L (2026). [PMID: 41271173](https://pubmed.ncbi.nlm.nih.gov/41271173/). *Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology*. [Case Report / Case Series]
Liao L (2026). [PMID: 42018214](https://pubmed.ncbi.nlm.nih.gov/42018214/). *Esophagus*. [Basic Science / Preclinical]
Zhang Y (2026). [PMID: 41638770](https://pubmed.ncbi.nlm.nih.gov/41638770/). *BMJ case reports*. [Clinical Trial Publication]
Peng L (2026). [PMID: 41791142](https://pubmed.ncbi.nlm.nih.gov/41791142/). *Clinical oncology (Royal College of Radiologists (Great Britain))*. [Case Report / Case Series]
Nakajima T (2026). [PMID: 41642718](https://pubmed.ncbi.nlm.nih.gov/41642718/). *J Radiat Res*. [Basic Science / Preclinical]
Köylü B (2026). [PMID: 41902878](https://pubmed.ncbi.nlm.nih.gov/41902878/). *Immunotherapy*. [Case Report / Case Series]
Yin X (2026). [PMID: 41912432](https://pubmed.ncbi.nlm.nih.gov/41912432/). *Oncologist*. [Epidemiology / Natural History]
AI-curated news mentioning esophageal small cell neuroendocrine carcinoma
Updated May 10, 2026
A recent study highlights adolescent-onset primary small cell neuroendocrine carcinoma of the nasal cavity as a rare and aggressive cancer, yet with a favorable outcome. This research contributes to the understanding of this uncommon disease and its clinical implications.
A new expert consensus has been published on the multidisciplinary diagnosis and treatment of small cell carcinoma of the esophagus. This 2026 edition aims to enhance clinical practices and improve patient outcomes.
A recent study details the clinicopathological and molecular genetic characteristics of Epstein-Barr virus-positive small cell neuroendocrine carcinoma of the nasopharynx. This research enhances understanding of the disease's genetic profile and potential therapeutic targets.