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esthesioneuroblastoma - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

esthesioneuroblastoma

MONDO:0016029

Also known as:olfactory neuroblastoma

Find Clinical TrialsTrials

Overview

A rare malignant neoplasm of the sinonasal cavity, arising from the basal layers of olfactory neuroepithelial cells in the superior nasal vault, which usually occurs in the 5th to 6th decades of life and is characterized clinically by non-specific symptoms such as progressive ipsilateral nasal block, sinusitis, facial pain, intermittent headaches, hyposmia/dysosmia, rhinorrhea and epistaxis as well as proptosis, diplopia and excessive lacrimation due to orbital extension. With early treatment and in the absence of distant metastases, ENB appears to have a good prognosis (compared to other superior nasal malignancies), despite a high rate of cervical metastases.

Clinical Trials11 registered · 8 recruiting

Diagnosis

Biomarker and diagnostic research for esthesioneuroblastoma has been reported in the published literature.

Prognosis

Estimated prevalence: <1 in 1,000,000 (VERY_RARE).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

11 clinical trials registered, 8 recruiting. Interventions under study include drug therapy, other interventions, and procedural interventions. Pipeline includes 1 PHASE4, 4 PHASE2, 3 PHASE1. Research is primarily sponsored by academic and government institutions.

NCT ID	Title	Phase	Sponsor	Status
[NCT06607692](https://clinicaltrials.gov/study/NCT06607692)

Data assembled from 4 of 12 sources · Last updated Sep 19, 2026, 4:30 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:1957

GARD

Genetic and Rare Diseases Info Center

GARD:2197

Questions for Your Care Team

→Are any of the 11 active clinical trials a good fit for my situation?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

← Back to All Diseases

Research Type	Count	% of Total
Research summaries	30	23%
Patient case studies	28	22%
Clinical study results	21	16%
Testing and diagnosis research	13	10%
Laboratory research	13	10%
Disease patterns and progression	12	9%
Other research	6	5%
New treatment approaches	6	5%

esthesioneuroblastoma

Overview

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

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