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Exercise-induced hyperinsulinism (EIHI) is a form of diazoxide-sensitive diffuse hyperinsulinism (DHI) characterized by episodes of hypoglycemia induced by exercise due to an inappropriate lactate and pyruvate sensitivity in pancreatic beta-cells.
Features include: Pancreatic islet-cell hyperplasia, Hyperinsulinemic hypoglycemia, Hypoglycemic seizures, and Hypoglycemia and 1 more.
Organ System | Phenotype Count | Example Features |
|---|---|---|
Digestive system | 1 | Pancreatic islet-cell hyperplasia |
Brain and nerves | 1 | Hypoglycemic seizures |
SLC16A1 function has not been fully characterized.
Exercise-induced hyperinsulinism is associated with mutations in the SLC16A1 gene on chromosome 1.
Genetic testing for SLC16A1 is available. Testing is considered confirmatory for diagnosis.
Estimated prevalence: <1 in 1,000,000 (VERY_RARE).
No clinical trials have been registered for exercise-induced hyperinsulinism.
4 publications have been identified in PubMed for exercise-induced hyperinsulinism. Research spans Case Report / Case Series (50%), Review / Meta-Analysis (25%), and Basic Science / Preclinical (25%).
Zhang QT (2026). [PMID: 41582760](https://pubmed.ncbi.nlm.nih.gov/41582760/). *Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics*. [Review / Meta-Analysis]
Gu L (2026). [PMID: 41659588](https://pubmed.ncbi.nlm.nih.gov/41659588/). *bioRxiv : the preprint server for biology*. [Basic Science / Preclinical]
Sigal W (2026). [PMID: 39778536](https://pubmed.ncbi.nlm.nih.gov/39778536/). *Horm Res Paediatr*. [Case Report / Case Series]
Frampton R (2025). [PMID: 39715334](https://pubmed.ncbi.nlm.nih.gov/39715334/). *European journal of endocrinology*. [Case Report / Case Series]
Data assembled from 6 of 12 sources · Last updated Sep 17, 2026, 7:31 PM UTC
Online Mendelian Inheritance in Man
European rare disease database
Genetic and Rare Diseases Info Center