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facial onset sensory and motor neuronopathy - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

facial onset sensory and motor neuronopathy

MONDO:0019405

Also known as:FOSMN syndromefacial onset sensorimotor neuronopathy syndromefacial onset sensory and motor neuronopathy syndrome

Overview

Facial onset sensory and motor neuronopathy is characterized initially by paraesthesia and numbness in the region of the trigeminal nerve distribution, which later progresses to involve the scalp, neck, upper trunk and upper limbs. Onset of motor manifestations occurs later with cramps, fasciculations, dysphagia, dysarthria, muscle weakness and atrophy. This syndrome has been described in four males and appears to be a slowly progressive neurodegenerative disease.

Diagnosis

Biomarker and diagnostic research for facial onset sensory and motor neuronopathy has been reported in the published literature.

Prognosis

Estimated prevalence: <1 in 1,000,000 (VERY_RARE).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for facial onset sensory and motor neuronopathy.

10 publications have been identified in PubMed for facial onset sensory and motor neuronopathy. Research spans Case Report / Case Series (50%), Epidemiology / Natural History (20%), and Diagnostic / Biomarker (10%).

Research Type	Count	% of Total
Patient case studies	5	50%

Data assembled from 3 of 12 sources · Last updated Sep 20, 2026, 5:34 AM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:85162

GARD

Genetic and Rare Diseases Info Center

GARD:12036

Questions for Your Care Team

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facial onset sensory and motor neuronopathy

Overview

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

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