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factor VII and Factor VIII, combined deficiency of - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

factor VII and Factor VIII, combined deficiency of

MONDO:0007595

Also known as:factor 7 and Factor VIII, combined deficiency offamilial multiple coagulation Factor deficiency 4multiple coagulation Factor deficiency 4

Overview

GeneticsAutosomal dominant

Clinical Presentation

Built from Human Phenotype Ontology (HPO) phenotype annotations and GeneReviews clinical descriptions. Features represent findings documented across known cases — not an exhaustive list of possible symptoms.

Features include: Reduced factor VIII activity, Intestinal bleeding, and Reduced factor VII activity.

Organ System	Phenotype Count	Example Features
Digestive system	1	Intestinal bleeding
Blood and immune system

Diagnosis

Biomarker and diagnostic research for factor VII and Factor VIII, combined deficiency of has been reported in the published literature.

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for factor VII and Factor VIII, combined deficiency of.

35 publications have been identified in PubMed for factor VII and Factor VIII, combined deficiency of. Research spans Case Report / Case Series (29%), Epidemiology / Natural History (26%), and Basic Science / Preclinical (23%).

Research Type	Count	% of Total
Patient case studies	10	29%

Data assembled from 4 of 12 sources · Last updated Sep 20, 2026, 6:22 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

OMIM

Online Mendelian Inheritance in Man

OMIM:134430

Questions for Your Care Team

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Kisho

factor VII and Factor VIII, combined deficiency of

Overview

Clinical Presentation

Diagnosis

Research Landscape

Medical References

External Resources

OMIM

Questions for Your Care Team

Questions for Your Care Team

Explore clinical features

Recent Publications

factor VII and Factor VIII, combined deficiency of

Overview

Clinical Presentation

Diagnosis

Research Landscape

Medical References

External Resources

OMIM

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Explore clinical features

Recent Publications