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Familial acute necrotizing encephalopathy or ADANE is a potentially fatal neurological disease characterized by neuropathological lesions principally involving the brainstem, thalamus and putamen.
Features include sometimes findings: Tetraplegia. 11 total HPO annotations.
Organ System | Phenotype Count | Example Features |
|---|---|---|
Brain and nerves | 5 | Encephalopathy, Spastic tetraplegia, Seizure |
Lungs and breathing |
Estimated prevalence: <1 in 1,000,000 (VERY_RARE).
No clinical trials have been registered for familial acute necrotizing encephalopathy.
3 publications have been identified in PubMed for familial acute necrotizing encephalopathy. Research spans Case Report / Case Series (100%).
Wong KS (2025). [PMID: 40179479](https://pubmed.ncbi.nlm.nih.gov/40179479/). *Clin Neurol Neurosurg*. [Case Report / Case Series]
Beigh SA (2025). [PMID: 40291183](https://pubmed.ncbi.nlm.nih.gov/40291183/). *Cureus*. [Case Report / Case Series]
Sivasubramanian D (2024). [PMID: 39310623](https://pubmed.ncbi.nlm.nih.gov/39310623/). *Cureus*. [Case Report / Case Series]
Data assembled from 5 of 12 sources · Last updated Sep 19, 2026, 11:56 AM UTC
Online Mendelian Inheritance in Man
European rare disease database
Genetic and Rare Diseases Info Center
1
Pneumonia |
Immune system | 1 | Abnormality of the immune system |
Lab test results | 1 | Increased CSF protein concentration |
AI-curated news mentioning familial acute necrotizing encephalopathy
Updated Aug 21, 2026
A recent study presents two case reports of familial acute necrotizing encephalopathy linked to SARS-CoV-2 infection, contributing to the understanding of this rare neurological condition. The literature review highlights the need for further research into the mechanisms and implications of this association.
A case study published in PubMed highlights acute hemorrhagic necrotizing encephalopathy in a COVID-19 patient who responded positively to intravenous immunoglobulin therapy. This research adds to the understanding of neurological complications associated with COVID-19.