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familial Alzheimer-like prion disease - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

familial Alzheimer-like prion disease

MONDO:0017233

Overview

ResearchLimited published research (4 articles)

Clinical Presentation

Built from Human Phenotype Ontology (HPO) phenotype annotations and GeneReviews clinical descriptions. Features represent findings documented across known cases — not an exhaustive list of possible symptoms.

Features include very common findings: Atypical behavior, Emotional lability, Depression, and Anxiety and others.

Organ System	Phenotype Count	Example Features
Brain and nerves	7	Atypical behavior, Emotional lability, Depression
Digestive system

Diagnosis

Biomarker and diagnostic research for familial Alzheimer-like prion disease has been reported in the published literature.

Prognosis

Phenotype severity distribution: 12 very common features.

Estimated prevalence: <1 in 1,000,000 (VERY_RARE).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for familial Alzheimer-like prion disease.

4 publications have been identified in PubMed for familial Alzheimer-like prion disease. Research spans Case Report / Case Series (50%), Diagnostic / Biomarker (25%), and Review / Meta-Analysis (25%).

Recent Publications

Holm-Mercer L (2025). [PMID: 39789805](https://pubmed.ncbi.nlm.nih.gov/39789805/). *Journal of neurogenetics*. [Diagnostic / Biomarker]
Strodel B (2025). [PMID: 40641247](https://pubmed.ncbi.nlm.nih.gov/40641247/). *BioEssays : news and reviews in molecular, cellular and developmental biology*. [Review / Meta-Analysis]
Nishikawa M (2025). [PMID: 40058853](https://pubmed.ncbi.nlm.nih.gov/40058853/). *Internal medicine (Tokyo, Japan)*. [Case Report / Case Series]
Qiao M (2024). [PMID: 39716111](https://pubmed.ncbi.nlm.nih.gov/39716111/). *BMC neurology*. [Case Report / Case Series]

Data assembled from 4 of 12 sources · Last updated Sep 20, 2026, 1:27 AM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:280397

GARD

Genetic and Rare Diseases Info Center

GARD:21084

Questions for Your Care Team

→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

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Kisho

familial Alzheimer-like prion disease

Overview

Clinical Presentation

Diagnosis

Prognosis

Research Landscape

Recent Publications

Medical References

External Resources

Orphanet

GARD

Questions for Your Care Team

Questions for Your Care Team

Explore clinical features

Latest News & Developments

Estimating the Penetrance of PRNP Mutations in Chinese Prion Disease Patients based on the Genome Databases.

Multi-target approaches to prion disease Drug discovery: a status update.

familial Alzheimer-like prion disease

Overview

Clinical Presentation

Diagnosis

Prognosis

Research Landscape

Recent Publications

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Explore clinical features

Latest News & Developments

Estimating the Penetrance of PRNP Mutations in Chinese Prion Disease Patients based on the Genome Databases.

Multi-target approaches to prion disease Drug discovery: a status update.