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familial clubfoot with or without associated lower limb anomalies - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

familial clubfoot with or without associated lower limb anomalies

MONDO:0016046

Overview

Familial clubfoot with or without associated lower limb anomalies is a rare congenital limb malformation syndrome characterized by malalignment of the bones and joints of the foot and ankle, with presence of forefoot and midfoot adductus, hindfoot varus, and ankle equinus, presenting as rigid inward turning of the foot towards the midline, in various members of a single family. Hypoplasia of lower leg muscles is a frequently associated finding. Patients may present with other low-limb malformations, such as patellar hypoplasia, oblique talus, tibial hemimelia, and polydactyly.

OnsetCONGENITAL

Diagnosis

Biomarker and diagnostic research for familial clubfoot with or without associated lower limb anomalies has been reported in the published literature.

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for familial clubfoot with or without associated lower limb anomalies.

202 publications have been identified in PubMed for familial clubfoot with or without associated lower limb anomalies. Kisho has analyzed 142 by research type. Research spans Case Report / Case Series (28%), Epidemiology / Natural History (26%), and Review / Meta-Analysis (25%).

Research Type	Count	% of Total
Patient case studies	40

Data assembled from 3 of 12 sources · Last updated Sep 20, 2026, 9:35 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:199315

GARD

Genetic and Rare Diseases Info Center

GARD:17093

Questions for Your Care Team

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familial clubfoot with or without associated lower limb anomalies

Overview

Diagnosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Subtypes

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

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