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familial supernumerary nipples - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

familial supernumerary nipples

MONDO:0008101

Also known as:isolated polytheliaaccessory nipplesnipples, supernumerary

Overview

Familial supernumerary nipples is a rare breast malformation characterized by the presence, in various members of a single family, of one or more nipple(s) and/or their related tissue, in addition to the normal bilateral chest nipples. The anomaly is usually situated along the embryonic milk line, from axillae to inguinal regions, but other locations are also possible. Association with dental abnormalities, Becker nevus, renal or underlying breast tissue malignancy and genitourinary malformations has been reported.

GeneticsAutosomal dominant

ResearchLimited published research (5 articles)

Clinical Presentation

Features include: Abnormality of the kidney, Supernumerary nipple, and Abnormal thorax morphology.

Organ System	Phenotype Count	Example Features
Kidneys and urinary system	1	Abnormality of the kidney

Explore clinical features

Prognosis

Estimated prevalence: <1 in 1,000,000 (VERY_RARE).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for familial supernumerary nipples.

5 publications have been identified in PubMed for familial supernumerary nipples. Research spans Case Report / Case Series (60%), Basic Science / Preclinical (20%), and Epidemiology / Natural History (20%).

Recent Publications

Rishabh RK (2026). [PMID: 42220602](https://pubmed.ncbi.nlm.nih.gov/42220602/). *JCEM Case Rep*. [Case Report / Case Series]
Lewis J (2025). [PMID: 40661071](https://pubmed.ncbi.nlm.nih.gov/40661071/). *SAGE Open Med Case Rep*. [Case Report / Case Series]
Danbaki AS (2025). [PMID: 41296379](https://pubmed.ncbi.nlm.nih.gov/41296379/). *Curr Issues Mol Biol*. [Epidemiology / Natural History]
Al Assaad M (2025). [PMID: 40396943](https://pubmed.ncbi.nlm.nih.gov/40396943/). *Int J Surg Pathol*. [Basic Science / Preclinical]
Tomey VS (2024). [PMID: 39464942](https://pubmed.ncbi.nlm.nih.gov/39464942/). *J Family Med Prim Care*. [Case Report / Case Series]

Data assembled from 5 of 12 sources · Last updated Sep 20, 2026, 11:21 AM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

OMIM

Online Mendelian Inheritance in Man

OMIM:163700

Orphanet

European rare disease database

Orphanet:2456

GARD

Genetic and Rare Diseases Info Center

GARD:2259

Questions for Your Care Team

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familial supernumerary nipples

Overview

Clinical Presentation

Explore clinical features

Prognosis

Research Landscape

Recent Publications

Medical References

External Resources

OMIM

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team