Question 1

What is Feingold syndrome?

Accepted Answer

Feingold syndrome is a rare inherited malformation syndrome. It is also known as oculo-digito-esophageal-duodenal (ODED) syndrome among other names. This condition is mainly characterized by a smaller head size (microcephaly), short stature, and a variety of digital anomalies (affecting the fingers and toes).

There are two subtypes of Feingold syndrome: type 1 (FS1) and type 2 (FS2). Type 1 is the most common form and may include gastrointestinal atresia (blockages) and short palpebral fissures (narrow eye openings). Type 2 shows similar features to type 1, but without the gastrointestinal atresia and the short palpebral fissures. This summary is based on published definitions and recognized descriptions.

Question 2

What are the symptoms of Feingold syndrome?

Accepted Answer

People with Feingold syndrome can have several common features including microcephaly (a smaller head size), short stature, and various abnormalities in their digits (fingers and toes). In the more common type 1, symptoms may also include issues related to the gastrointestinal tract and differences in the appearance of the eyes. These features can vary in severity among individuals.

Question 3

What causes Feingold syndrome?

Accepted Answer

Feingold syndrome is an inherited condition. It is passed down in families, although specific genetic details such as the known genes have not been provided in the available information. Inheritance plays a key role in the development of this condition. Associated genes include MYCN.

Question 4

How rare is Feingold syndrome?

Accepted Answer

Feingold syndrome is classified as very rare. The estimated prevalence is approximately <1 in 1,000,000. Because rare disease data can be limited, actual numbers may differ from published estimates.

Question 5

How is Feingold syndrome diagnosed?

Accepted Answer

Information about diagnosis is currently limited for this condition.

Question 6

Are there treatments for Feingold syndrome?

Accepted Answer

Information about treatment is currently limited for this condition.

Question 7

What complications can arise from Feingold syndrome?

Accepted Answer

Feingold syndrome can lead to various complications, especially in type 1. Some individuals may experience gastrointestinal atresia, which means there are blockages in the digestive tract. This can cause feeding difficulties and require medical intervention. Additionally, the digital anomalies may affect hand and foot function, impacting daily activities.

Question 8

How does Feingold syndrome affect daily life for individuals?

Accepted Answer

Daily life for individuals with Feingold syndrome can vary widely. Some may need assistance with tasks due to short stature or digital anomalies, while others may face challenges related to feeding or gastrointestinal issues. Support from family and healthcare providers can help improve their quality of life and independence.

Question 9

What is the life expectancy for someone with Feingold syndrome?

Accepted Answer

Information about life expectancy for individuals with Feingold syndrome is currently limited. However, many people with this condition can lead fulfilling lives, especially with proper medical care and support. It's important to work closely with healthcare professionals to manage symptoms and any complications that may arise.

Question 10

Are there specific specialists that should be involved in the care of someone with Feingold syndrome?

Accepted Answer

Yes, individuals with Feingold syndrome may benefit from a team of specialists. This can include pediatricians, geneticists, and gastroenterologists, especially if gastrointestinal issues are present. Occupational and physical therapists may also be helpful for managing digital anomalies and improving daily function.

Brachymesophalangy	100%
Facial dysmorphism	Short palpebral fissures
Atresia	Esophageal
Other	Renal abnormalities

Gene(s)	Disorder	MOI	Clinical Features of Differential Diagnosis Disorder
CHARGE syndrome	AD	Esophageal atresia; Heart defects; Renal abnormalities	Coloboma; Genital abnormalities
Ear anomalies MIR17HG1	Feingold syndrome 2(OMIM 614326)	AD

System/Concern	Evaluation	Comment
Hands/Feet	Assess for digital anomalies.	Hand surgeon; Occupational therapy to assess hand function/ need for therapy; Foot specialist to assess for functional needs
Gastrointestinal tract	Assess for gastrointestinal atresia (incl esophageal, duodenal, jejunal, anal).	Gastroenterologist/ GI surgeon
Development	Developmental assessment	Incl eval of motor, speech-language, general cognitive, vocational skills
Renal abnormalities	Renal ultrasound eval	Assess for renal anomalies.
Cardiac abnormalities	Assess for congenital heart defects.	Pediatric cardiologist
Hearing loss	Audiologic eval1	Conductive sensorineural
Miscellaneous	Consultation w/clinical geneticist /or genetic counselor	1. See Hereditary Hearing Loss and Deafness Overview for details about audiologic evaluations.

System/Concern	Evaluation	Frequency
Hands/Feet	Hand function / need for OT	Per OT
GI tract atresia	As specified by GI consultants	Per GI consultants Development/
Education	Monitor developmental progress educational needs.	Routinely, per developmental pediatrician /or school
Renal	As specified by renal consultants	Per renal consultants
Cardiac	As specified by cardiac consultants	Per cardiologist
Hearing	Audiologic reexamination to determine type extent of hearing loss success w/hearing habilitation	Per treating audiologist GI = gastrointestinal; OT = occupational therapist/therapy

Kisho

Feingold syndrome

Overview

Clinical Presentation

Clinical Guidance

Diagnosis

Diagnostic Criteria

Suggestive Findings

Establishing the Diagnosis

Differential Diagnosis

Treatment

Management Guidelines

Therapies Under Investigation

Clinical Trials

Prognosis

Surveillance Guidelines

Research Landscape

Recent Publications

Medical References

External Resources

Orphanet

GARD

Questions for Your Care Team

Questions for Your Care Team

FAQ

Frequently Asked Questions

Feingold syndrome

Overview

Clinical Presentation

Clinical Guidance

Diagnosis

Diagnostic Criteria

Suggestive Findings

Establishing the Diagnosis

Differential Diagnosis

Treatment

Management Guidelines

Therapies Under Investigation

Clinical Trials

Prognosis

Surveillance Guidelines

Research Landscape

Recent Publications

Medical References

External Resources

Orphanet

GARD

Subtypes

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

FAQ

Frequently Asked Questions

What is Feingold syndrome?

What are the symptoms of Feingold syndrome?

What causes Feingold syndrome?

How rare is Feingold syndrome?

How is Feingold syndrome diagnosed?

Are there treatments for Feingold syndrome?

What complications can arise from Feingold syndrome?

How does Feingold syndrome affect daily life for individuals?

What is the life expectancy for someone with Feingold syndrome?

Are there specific specialists that should be involved in the care of someone with Feingold syndrome?