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fibronectin glomerulopathy (GFND) - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

fibronectin glomerulopathy

MONDO:0007671

Also known as:GFNDglomerulopathy with fibronectin depositsGFND1

Overview

A hereditary kidney disease characterized by proteinuria, type IV renal tubular acidosis, microscopic hematuria and hypertension that may lead to end-stage renal failure in the second to sixth decade of life.

ResearchLimited published research (9 articles)

Clinical Presentation

Built from Human Phenotype Ontology (HPO) phenotype annotations and GeneReviews clinical descriptions. Features represent findings documented across known cases — not an exhaustive list of possible symptoms.

Features include very common findings: Reduced kidney function (renal insufficiency), Protein in the urine (proteinuria), Nephrotic syndrome, and Hypertension and others; and sometimes findings: Cerebral hemorrhage.

Organ System	Phenotype Count	Example Features
Kidneys and urinary system	6	Reduced kidney function (renal insufficiency), Protein in the urine (proteinuria), Nephrotic syndrome

Prognosis

Phenotype severity distribution: 9 very common features.

Estimated prevalence: <1 in 1,000,000 (VERY_RARE).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for fibronectin glomerulopathy.

9 publications have been identified in PubMed for fibronectin glomerulopathy. Research spans Case Report / Case Series (100%).

Recent Publications

Sannino A (2026). [PMID: 42143752](https://pubmed.ncbi.nlm.nih.gov/42143752/). *G Ital Nefrol*. [Case Report / Case Series]
Shi B (2026). [PMID: 41642109](https://pubmed.ncbi.nlm.nih.gov/41642109/). *Clinical nephrology*. [Case Report / Case Series]
Chen X (2026). [PMID: 42068364](https://pubmed.ncbi.nlm.nih.gov/42068364/). *Pediatr Nephrol*. [Case Report / Case Series]
Wei J (2026). [PMID: 42150947](https://pubmed.ncbi.nlm.nih.gov/42150947/). *Transplant Proc*. [Case Report / Case Series]
Nagayama Y (2025). [PMID: 40120032](https://pubmed.ncbi.nlm.nih.gov/40120032/). *CEN case reports*. [Case Report / Case Series]
Tsighe AZ (2025). [PMID: 40529320](https://pubmed.ncbi.nlm.nih.gov/40529320/). *Case reports in nephrology and dialysis*. [Case Report / Case Series]

Data assembled from 4 of 12 sources · Last updated Sep 18, 2026, 7:12 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:84090

GARD

Genetic and Rare Diseases Info Center

GARD:15019

Questions for Your Care Team

→Are there specialists or centers of excellence for this condition in my area?
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Kisho

fibronectin glomerulopathy

Overview

Clinical Presentation

Prognosis

Research Landscape

Recent Publications

Medical References

External Resources

Orphanet

GARD

Questions for Your Care Team

Questions for Your Care Team

Explore clinical features

Latest News & Developments

Successful Control of Late-Onset Nephrotic Syndrome in FN1-Associated Fibronectin Glomerulopathy: A 17-Year Clinical Course.

Concomitant Fibronectin Glomerulopathy and Chronic Active Antibody-mediated Rejection in a Renal Allograft: A Case Report and Literature Review.

fibronectin glomerulopathy

Overview

Clinical Presentation

Prognosis

Research Landscape

Recent Publications

Medical References

External Resources

Orphanet

GARD

Subtypes

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Explore clinical features

Latest News & Developments

Successful Control of Late-Onset Nephrotic Syndrome in FN1-Associated Fibronectin Glomerulopathy: A 17-Year Clinical Course.

Concomitant Fibronectin Glomerulopathy and Chronic Active Antibody-mediated Rejection in a Renal Allograft: A Case Report and Literature Review.