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filarial elephantiasis - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

filarial elephantiasis

MONDO:0005761

Also known as:ElephantiasisBancroftian elephantiasisBancroftian filarial chyluria

Find Clinical TrialsTrials

Overview

Parasitic infestation of the human lymphatic system by wuchereria bancrofti or brugia malayi. It is also called lymphatic filariasis.

Clinical Trials1 registered · 1 recruiting

Clinical Presentation

Built from Human Phenotype Ontology (HPO) phenotype annotations and GeneReviews clinical descriptions. Features represent findings documented across known cases — not an exhaustive list of possible symptoms.

Features include very common findings: Lymphedema, Lymphadenopathy, Predominantly lower limb lymphedema, and Abnormality of the lymphatic system; and common findings: Hyperpigmentation of the skin, Thickened, rough skin (hyperkeratosis), Lymphadenitis, and Circulating immune complexes and others. 33 total HPO annotations.

Organ System	Phenotype Count	Example Features
Kidneys and urinary system	5	Abnormality of the kidney, Protein in the urine (proteinuria), Glomerulonephritis

Diagnosis

Biomarker and diagnostic research for filarial elephantiasis has been reported in the published literature.

Prognosis

Phenotype severity distribution: 4 very common features, 7 common features.

Estimated prevalence: <1 in 1,000,000 (VERY_RARE).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

1 clinical trial registered, 1 recruiting. Interventions under study include drug therapy. Research is primarily sponsored by academic and government institutions.

128 publications have been identified in PubMed for filarial elephantiasis. Research spans Epidemiology / Natural History (35%), Review / Meta-Analysis (26%), and Clinical Trial Publication (13%).

Research Type	Count	% of Total
Disease patterns and progression	45	35%

Data assembled from 5 of 12 sources · Last updated Sep 18, 2026, 7:13 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:2035

GARD

Genetic and Rare Diseases Info Center

GARD:3321

Questions for Your Care Team

→Are any of the 1 active clinical trial a good fit for my situation?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

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filarial elephantiasis

Overview

Clinical Presentation

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Questions for Your Care Team

Questions for Your Care Team

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Recent Publications

filarial elephantiasis

Overview

Clinical Presentation

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Explore clinical features

Recent Publications