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Follicular cholangitis and pancreatitis is a rare pancreatobiliary disease characterized by marked duct-centered lymphoid follicular inflammation that develops in both biliary and pancreatic ductal systems, mainly affecting the hilar bile ducts and the pancreatic head. Patients present with jaundice, abdominal pain, liver dysfunction, pruritus and/or weight loss. Histology shows lymphoplasmacytic infiltration with formation of numerous, large lymphpoid follicles around the affected bile and pancreatic ducts.
Estimated prevalence: <1 in 1,000,000 (VERY_RARE).
No clinical trials have been registered for follicular cholangitis and pancreatitis.
4 publications have been identified in PubMed for follicular cholangitis and pancreatitis. Research spans Review / Meta-Analysis (50%) and Case Report / Case Series (50%).
Keitel V (2026). [PMID: 41371348](https://pubmed.ncbi.nlm.nih.gov/41371348/). *Journal of hepatology*. [Case Report / Case Series]
Ren X (2026). [PMID: 41728618](https://pubmed.ncbi.nlm.nih.gov/41728618/). *Frontiers in medicine*. [Review / Meta-Analysis]
Wu S (2025). [PMID: 40599784](https://pubmed.ncbi.nlm.nih.gov/40599784/). *Frontiers in immunology*. [Review / Meta-Analysis]
Jung Y (2024). [PMID: 39051325](https://pubmed.ncbi.nlm.nih.gov/39051325/). *Dermatopathology (Basel, Switzerland)*. [Case Report / Case Series]
Data assembled from 3 of 12 sources · Last updated Sep 18, 2026, 11:36 PM UTC
European rare disease database
Genetic and Rare Diseases Info Center