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An autonomic disorder characterized by excessive sweating of the forehead, upper lip, perioral region, or sternum subsequent to gustatory stimuli. The auriculotemporal syndrome features facial flushing or sweating limited to the distribution of the auriculotemporal nerve and may develop after trauma to the parotid gland, in association with parotid neoplasms, or following their surgical removal. (From Ann Neurol 1997 Dec;42(6):973-5)
Features include: Excessive sweating (hyperhidrosis).
Organ System | Phenotype Count | Example Features |
|---|---|---|
Skin | 1 | Excessive sweating (hyperhidrosis) |
No approved treatments are currently available for Frey syndrome. An additional 1 compound holds orphan drug designation.
While no drugs are FDA-approved specifically for Frey syndrome, some of the following designated compounds may be used off-label in clinical practice. Treatment decisions should be made in consultation with a specialist familiar with this condition.
The following drugs have received orphan drug designation from the FDA for Frey syndrome. Orphan designation reflects regulatory interest and does not indicate approval for treatment.
Brand Name | Generic Name | Sponsor |
|---|
Estimated prevalence: Unknown (Unknown prevalence).
No clinical trials have been registered for Frey syndrome.
54 publications have been identified in PubMed for Frey syndrome. Research spans Clinical Trial Publication (35%), Case Report / Case Series (24%), and Review / Meta-Analysis (19%).
Research Type | Count | % of Total |
|---|---|---|
Clinical study results | 19 | 35% |
Data assembled from 6 of 12 sources · Last updated Sep 20, 2026, 3:00 PM UTC
Online Mendelian Inheritance in Man
European rare disease database
Common questions about Frey syndrome
Designated
Exclusivity End |
|---|
Designation Status |
|---|
glycopyrrolate 2% | glycopyrrolate 2% | Wellesley Therapeutics, Inc. | 2010 | — | Designated |
Gene therapy approaches for Frey syndrome have been reported in the published literature.
View trials for Frey syndrome
13 |
24% |
Research summaries | 10 | 19% |
Disease patterns and progression | 6 | 11% |
Other research | 3 | 6% |
New treatment approaches | 3 | 6% |
Drozdowski-Nuccio V (2026). [PMID: 42057908](https://pubmed.ncbi.nlm.nih.gov/42057908/). *Laryngoscope Investig Otolaryngol*. [Review / Meta-Analysis]
Rourk KS (2026). [PMID: 42152554](https://pubmed.ncbi.nlm.nih.gov/42152554/). *Ann Otol Rhinol Laryngol*. [Epidemiology / Natural History]
Lee N (2026). [PMID: 41240992](https://pubmed.ncbi.nlm.nih.gov/41240992/). *Journal of the American Academy of Dermatology*. [Case Report / Case Series]
Young A (2026). [PMID: 32965918](https://pubmed.ncbi.nlm.nih.gov/32965918/). *Unknown Journal*. [Other]
Semaan M (2026). [PMID: 41691340](https://pubmed.ncbi.nlm.nih.gov/41691340/). *Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology*. [Clinical Trial Publication]
Müller SK (2026). [PMID: 41677806](https://pubmed.ncbi.nlm.nih.gov/41677806/). *HNO*. [Gene Therapy / Novel Therapeutics]
Osman T (2026). [PMID: 41781946](https://pubmed.ncbi.nlm.nih.gov/41781946/). *BMC oral health*. [Case Report / Case Series]
Dağdelen D (2026). [PMID: 41744413](https://pubmed.ncbi.nlm.nih.gov/41744413/). *The Journal of craniofacial surgery*. [Clinical Trial Publication]
Vyas U (2026). [PMID: 41729338](https://pubmed.ncbi.nlm.nih.gov/41729338/). *Oral and maxillofacial surgery*. [Review / Meta-Analysis]
You YS (2026). [PMID: 42259063](https://pubmed.ncbi.nlm.nih.gov/42259063/). *Auris Nasus Larynx*. [Epidemiology / Natural History]