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functioning gonadotropic adenoma - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

functioning gonadotropic adenoma

MONDO:0019612

Also known as:functioning pituitary gonadotropic adenomagonadotroph adenoma

Overview

Functioning gonadotropic adenoma is a very rare pituitary tumor, macroscopically characterized by a soft, well vascularized, variable sized adenoma, with occasional areas of hemorrage or necrosis, that secretes biologically active gonadotropins. In addition to common neurological signs due to mass effect (headache and/or visual field deterioration), additional clinical manifestations include menstrual irregularities (secondary amenorrhea, oligomenorhea or severe menorrhagia), galactorrhea, infertility or ovarian hyperstimulation syndrome (in premenopausal women), testicular enlargement and, occasionally, hypogonadism (in men) and isosexual precocious puberty (in children).

Newborn Screening34 states (Malonic Acidemia)

Diagnosis

Functioning gonadotropic adenoma is included in newborn screening programs (Malonic Acidemia) in 34 states.

Biomarker and diagnostic research for functioning gonadotropic adenoma has been reported in the published literature.

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for functioning gonadotropic adenoma.

22 publications have been identified in PubMed for functioning gonadotropic adenoma. Research spans Case Report / Case Series (32%), Basic Science / Preclinical (27%), and Clinical Trial Publication (14%).

Research Type	Count	% of Total
Patient case studies	7	32%

Data assembled from 4 of 12 sources · Last updated Sep 18, 2026, 3:22 AM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:91348

GARD

Genetic and Rare Diseases Info Center

GARD:19158

Questions for Your Care Team

→What follow-up testing and early intervention is recommended after a positive newborn screen?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

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functioning gonadotropic adenoma

Overview

Diagnosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

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