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gastric mucosal hypertrophy - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

gastric mucosal hypertrophy

MONDO:0007652

Also known as:MENETRIER diseaseMenetrier's diseaseMénétrier disease

Overview

A rare premalignant hyperproliferative gastropathy characterized by massive overgrowth of foveolar cells in the gastric lining, resulting in large gastric folds, and manifesting with epigastric pain, nausea, vomiting, peripheral edema and, less commonly, anorexia and weight loss.

GeneticsAutosomal recessive

Clinical Presentation

Features include: Giant hypertrophic gastritis, Hypoproteinemia, and Vascular dilatation.

Organ System	Phenotype Count	Example Features
Heart and blood vessels	1	Giant hypertrophic gastritis

Explore clinical features

Diagnosis

Biomarker and diagnostic research for gastric mucosal hypertrophy has been reported in the published literature.

Prognosis

Estimated prevalence: Unknown (Unknown prevalence).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for gastric mucosal hypertrophy.

15 publications have been identified in PubMed for gastric mucosal hypertrophy. Research spans Case Report / Case Series (73%), Review / Meta-Analysis (20%), and Diagnostic / Biomarker (7%).

Research Type	Count	% of Total
Patient case studies	11	73%

Data assembled from 5 of 12 sources · Last updated Sep 20, 2026, 3:02 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

OMIM

Online Mendelian Inheritance in Man

OMIM:137280

Orphanet

European rare disease database

Orphanet:2494

GARD

Genetic and Rare Diseases Info Center

GARD:2436

Questions for Your Care Team

→Should my partner and I meet with a genetic counselor to discuss carrier status and family planning?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

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gastric mucosal hypertrophy

Overview

Clinical Presentation

Explore clinical features

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

OMIM

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Recent Publications