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Gelatinous drop-like corneal dystrophy (GDCD) is a form of superficial corneal dystrophy characterized by multiple prominent milky-white gelatinous nodules beneath the corneal epithelium, and marked visual impairment.
Data assembled from 6 of 12 sources · Last updated Sep 19, 2026, 11:55 AM UTC
Online Mendelian Inheritance in Man
European rare disease database
Genetic and Rare Diseases Info Center
Features include: Corneal foreign body sensation, Clouding of the cornea (corneal dystrophy), Photophobia, and Reduced visual acuity and 2 more.
Organ System | Phenotype Count | Example Features |
|---|---|---|
Eyes | 4 | Corneal foreign body sensation, Clouding of the cornea (corneal dystrophy), Visual impairment |
Age of onset: childhood, adulthood.
TACSTD2 function has not been fully characterized.
Gelatinous drop-like corneal dystrophy is associated with mutations in the TACSTD2 gene on chromosome 1.
Genetic testing for TACSTD2 is available. Testing is considered confirmatory for diagnosis.
Estimated prevalence: 1-9 in 1,000,000 (Rare).
No clinical trials have been registered for gelatinous drop-like corneal dystrophy.
10 publications have been identified in PubMed for gelatinous drop-like corneal dystrophy. Research spans Case Report / Case Series (63%), Review / Meta-Analysis (13%), and Epidemiology / Natural History (13%).
Qiu J (2026). [PMID: 42053878](https://pubmed.ncbi.nlm.nih.gov/42053878/). *Jpn J Ophthalmol*. [Case Report / Case Series]
Liskova P (2025). [PMID: 40079222](https://pubmed.ncbi.nlm.nih.gov/40079222/). *Clinical & experimental ophthalmology*. [Review / Meta-Analysis]
Luo JH (2025). [PMID: 39379186](https://pubmed.ncbi.nlm.nih.gov/39379186/). *Journal francais d'ophtalmologie*. [Case Report / Case Series]
Maimaitiming R (2025). [PMID: 40315281](https://pubmed.ncbi.nlm.nih.gov/40315281/). *Cornea*. [Case Report / Case Series]
Elhardt C (2025). [PMID: 40537778](https://pubmed.ncbi.nlm.nih.gov/40537778/). *BMC ophthalmology*. [Epidemiology / Natural History]
Abreu CB (2024). [PMID: 38619860](https://pubmed.ncbi.nlm.nih.gov/38619860/). *European journal of ophthalmology*. [Case Report / Case Series]
Abu Dail Y (2024). [PMID: 39177400](https://pubmed.ncbi.nlm.nih.gov/39177400/). *Cornea*. [Case Report / Case Series]
Skorodumova LO (2024). [PMID: 39013858](https://pubmed.ncbi.nlm.nih.gov/39013858/). *Human genome variation*. [Gene Therapy / Novel Therapeutics]