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A diverse group of pregnancy-related tumors characterized by excessive proliferation of trophoblasts. Representative examples include hydatidiform mole, gestational choriocarcinoma, and placental site trophoblastic tumor.
Biomarker and diagnostic research for gestational trophoblastic neoplasm has been reported in the published literature.
Estimated prevalence: Unknown (Unknown prevalence).
14 clinical trials registered, 6 recruiting. Interventions under study include drug therapy, other interventions, procedural interventions, and biologic therapy. Pipeline includes 1 PHASE3, 6 PHASE2, 3 NA. Research is primarily sponsored by academic and government institutions.
NCT ID | Title | Phase | Sponsor | Status |
|---|---|---|---|---|
[NCT06681259](https://clinicaltrials.gov/study/NCT06681259) |
Data assembled from 4 of 12 sources · Last updated Sep 18, 2026, 2:41 PM UTC
European rare disease database
Genetic and Rare Diseases Info Center
Clinical Specialty Queue For Gestational Trophoblastic Neoplasia |
— |
Women's Hospital School Of Medicine Zhejiang University |
RECRUITING |
[NCT06020755](https://clinicaltrials.gov/study/NCT06020755) | Toripalimab Plus Actinomycin-D As Fist-Line Treatment for GTN with FIGO Score 7 | PHASE2 | Peking Union Medical College Hospital | RECRUITING |
[NCT03785574](https://clinicaltrials.gov/study/NCT03785574) | Study of Different Therapeutic Strategies in Hydatidiform Mole With Lung Nodule | NA | Women's Hospital School Of Medicine Zhejiang University | RECRUITING |
[NCT06028672](https://clinicaltrials.gov/study/NCT06028672) | Toripalimab Plus Actinomycin-D as Fist-Line Treatment for GTN With FIGO Score 5-6 | NA | Peking Union Medical College Hospital | RECRUITING |
[NCT05139095](https://clinicaltrials.gov/study/NCT05139095) | Camrelizumab Plus Apatinib in Patients With High-risk Gestational Trophoblastic Neoplasia | PHASE2 | Peking Union Medical College Hospital | RECRUITING |
172 publications have been identified in PubMed for gestational trophoblastic neoplasm. Kisho has analyzed 136 by research type. Research spans Review / Meta-Analysis (45%), Case Report / Case Series (22%), and Epidemiology / Natural History (14%).
Research Type | Count | % of Total |
|---|---|---|
Research summaries | 61 | 45% |
Patient case studies | 30 | 22% |
Disease patterns and progression | 19 | 14% |
Other research | 9 | 7% |
Clinical study results | 8 | 6% |
Testing and diagnosis research | 7 | 5% |
Laboratory research | 1 | 1% |
New treatment approaches | 1 | 1% |
Farley JH (2026). [PMID: 42102342](https://pubmed.ncbi.nlm.nih.gov/42102342/). *Am Soc Clin Oncol Educ Book*. [Review / Meta-Analysis]
Tang X (2026). [PMID: 41978724](https://pubmed.ncbi.nlm.nih.gov/41978724/). *Int J Womens Health*. [Case Report / Case Series]
Madera EM (2026). [PMID: 42037835](https://pubmed.ncbi.nlm.nih.gov/42037835/). *Cureus*. [Case Report / Case Series]
Cue L (2026). [PMID: 29083593](https://pubmed.ncbi.nlm.nih.gov/29083593/). *Unknown Journal*. [Other]
Odgers H (2026). [PMID: 40501286](https://pubmed.ncbi.nlm.nih.gov/40501286/). *Aust N Z J Obstet Gynaecol*. [Review / Meta-Analysis]
Faure-Conter C (2026). [PMID: 41407594](https://pubmed.ncbi.nlm.nih.gov/41407594/). *Bull Cancer*. [Review / Meta-Analysis]
Bruce S (2026). [PMID: 29261918](https://pubmed.ncbi.nlm.nih.gov/29261918/). *Unknown Journal*. [Other]
Braga A (2026). [PMID: 41855543](https://pubmed.ncbi.nlm.nih.gov/41855543/). *Obstet Gynecol*. [Other]
Lin LH (2026). [PMID: 40644332](https://pubmed.ncbi.nlm.nih.gov/40644332/). *Int J Gynecol Pathol*. [Diagnostic / Biomarker]
AlJulaih GH (2026). [PMID: 32965896](https://pubmed.ncbi.nlm.nih.gov/32965896/). *Unknown Journal*. [Other]
AI-curated news mentioning gestational trophoblastic neoplasm
Updated Sep 7, 2026
A recent study explores the role of chemotherapy in treating high-risk gestational trophoblastic neoplasia, providing insights into treatment efficacy and patient outcomes. This research contributes to the understanding of therapeutic strategies for this rare condition.
A rare case report details a successful live birth via oocyte donation IVF in a 53-year-old patient with low-risk gestational trophoblastic neoplasia. This case highlights the potential for reproductive success in older patients following conservative management of this rare condition.
A systematic review and meta-analysis study provides insights into the epidemiology, histopathologic patterns, and clinical characteristics of gestational trophoblastic diseases in Ethiopia. This research enhances understanding of these rare conditions, which can inform future studies and clinical practices.