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giant cell myocarditis (GCM) - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

giant cell myocarditis

MONDO:0023232

Also known as:GCMidiopathic giant-cell myocarditis

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Overview

An often fatal inflammatory disorder that affects the myocardium. Morphologically, it is characterized by the presence of an inflammatory infiltrate in the myocardial tissue that includes multinucleated giant cells. It is often associated with the presence of an autoimmune disorder. Patients present with arrhythmias and/or heart failure. Heart transplantation is the only treatment option available.

Clinical Trials1 registered

Diagnosis

Biomarker and diagnostic research for giant cell myocarditis has been reported in the published literature.

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

1 clinical trial registered. Interventions under study include other interventions. Research is primarily sponsored by academic and government institutions.

40 publications have been identified in PubMed for giant cell myocarditis. Research spans Case Report / Case Series (55%), Review / Meta-Analysis (25%), and Epidemiology / Natural History (10%).

Research Type	Count	% of Total
Patient case studies	22	55%

Data assembled from 3 of 12 sources · Last updated Sep 19, 2026, 1:53 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

GARD

Genetic and Rare Diseases Info Center

GARD:6502

Questions for Your Care Team

→Are any of the 1 active clinical trial a good fit for my situation?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

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Kisho

giant cell myocarditis

Overview

Diagnosis

Research Landscape

Medical References

External Resources

GARD

Questions for Your Care Team

Questions for Your Care Team

Recent Publications

Latest News & Developments

Giant cell interstitial pneumonia associated with occupational iron exposure: an exceptional case report.

Giant cell myocarditis: from immune pathogenesis to contemporary management.

Giant Cell Urothelial Carcinoma: Morphometric Insights and Associations With Aggressive Clinical Features.

giant cell myocarditis

Overview

Diagnosis

Research Landscape

Medical References

External Resources

GARD

Subtypes

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Recent Publications

Latest News & Developments

Giant cell interstitial pneumonia associated with occupational iron exposure: an exceptional case report.

Giant cell myocarditis: from immune pathogenesis to contemporary management.

Giant Cell Urothelial Carcinoma: Morphometric Insights and Associations With Aggressive Clinical Features.