ITGA2B encodes integrin subunit alpha 2b (1,039 aa). Integrin alpha-IIb/beta-3 (ITGA2B:ITGB3) is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Highest expression in Whole Blood (32.7 TPM) and Spleen (16.6 TPM).

Glanzmann thrombasthenia 1 is associated with mutations in the ITGA2B gene on chromosome 17.

The ITGA2B protein participates in RUNX1 and GATA1 bind the promoter of the ITGA2B gene, PRMT6 arginine methylates H3K4me2-Nucleosome at the ITGA2B gene promoter, and RUNX1:CBFB, SIN3A(SIN3B), PRMT6 and HDAC1 bind the ITGA2B promoter pathways.

ITGA2B is classified as a druggable target (Cell Surface, Druggable Genome, and External Side Of Plasma Membrane categories) with score 3.6.

Genetic testing for ITGA2B is available. Testing is considered confirmatory for diagnosis.

Biomarker and diagnostic research for Glanzmann thrombasthenia 1 has been reported in the published literature.

Phenotype severity distribution: 9 always present features.

6 clinical trials registered, 4 recruiting. Interventions under study include other interventions, drug therapy, medical devices, and biologic therapy. Pipeline includes 1 PHASE2, 1 PHASE1, 1 NA. Research is sponsored by a mix of industry and academic institutions.

93 publications have been identified in PubMed for Glanzmann thrombasthenia 1. Research spans Case Report / Case Series (35%), Epidemiology / Natural History (22%), and Basic Science / Preclinical (14%).

Recent Publications

• Rutten KHG (2026). [PMID: 41403382](https://pubmed.ncbi.nlm.nih.gov/41403382/). *Haemophilia : the official journal of the World Federation of Hemophilia*. [Gene Therapy / Novel Therapeutics]

• Rutten KHG (2026). [PMID: 41614558](https://pubmed.ncbi.nlm.nih.gov/41614558/). *Platelets*. [Basic Science / Preclinical]

• Glonnegger H (2026). [PMID: 42082146](https://pubmed.ncbi.nlm.nih.gov/42082146/). *Hamostaseologie*. [Diagnostic / Biomarker]

• Ben Lamine Z (2026). [PMID: 41955421](https://pubmed.ncbi.nlm.nih.gov/41955421/). *Lab Med*. [Review / Meta-Analysis]

• Zibara V (2026). [PMID: 41874099](https://pubmed.ncbi.nlm.nih.gov/41874099/). *Hematol Rep*. [Review / Meta-Analysis]

• Zhang Y (2026). [PMID: 41510763](https://pubmed.ncbi.nlm.nih.gov/41510763/). *Platelets*. [Case Report / Case Series]

• Touré SA (2026). [PMID: 41630424](https://pubmed.ncbi.nlm.nih.gov/41630424/). *Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis*. [Epidemiology / Natural History]

• Zaninetti C (2026). [PMID: 41791656](https://pubmed.ncbi.nlm.nih.gov/41791656/). *Journal of thrombosis and haemostasis : JTH*. [Diagnostic / Biomarker]

• Quan ZR (2026). [PMID: 41846366](https://pubmed.ncbi.nlm.nih.gov/41846366/). *Zhongguo Shi Yan Xue Ye Xue Za Zhi*. [Diagnostic / Biomarker]

• Tiwari SK (2026). [PMID: 41265828](https://pubmed.ncbi.nlm.nih.gov/41265828/). *Journal of pediatric and adolescent gynecology*. [Case Report / Case Series]