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glaucoma secondary to spherophakia/ectopia lentis and megalocornea - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

glaucoma secondary to spherophakia/ectopia lentis and megalocornea

MONDO:0016559

Also known as:megalocornea-spherophakia-secondary glaucoma syndrome

Overview

Glaucoma secondary to spherophakia/ectopia lentis and megalocornea is a rare, genetic, non-syndromic developmental defect of the eye disorder characterized by congenital megalocornea associated with spherophakia and/or ectopia lentis leading to pupillary block and secondary glaucoma. Additional features may include flat irides, iridodonesis, axial myopia, very deep anterior chambers, miotic, oval pupils without well-defined borders, ocular pain and irritability manifesting as conjunctival injection, corneal edema and central scarring, as well as a high arched palate.

Diagnosis

Biomarker and diagnostic research for glaucoma secondary to spherophakia/ectopia lentis and megalocornea has been reported in the published literature.

Prognosis

Estimated prevalence: <1 in 1,000,000 (VERY_RARE).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for glaucoma secondary to spherophakia/ectopia lentis and megalocornea.

142 publications have been identified in PubMed for glaucoma secondary to spherophakia/ectopia lentis and megalocornea. Research spans Review / Meta-Analysis (37%), Epidemiology / Natural History (20%), and Basic Science / Preclinical (15%).

Research Type	Count	% of Total
Research summaries	53	37%

Data assembled from 3 of 12 sources · Last updated Sep 20, 2026, 5:52 AM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:238763

GARD

Genetic and Rare Diseases Info Center

GARD:10942

Questions for Your Care Team

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glaucoma secondary to spherophakia/ectopia lentis and megalocornea

Overview

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

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