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grade III glioma - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

grade III glioma

MONDO:0021640

Also known as:WHO grade III gliomaanaplastic glioma

Find Clinical TrialsTrials

Overview

A group of malignant gliomas that includes anaplastic astrocytoma, anaplastic oligodendroglioma, anaplastic oligoastrocytoma, and anaplastic ependymoma.

TreatmentsNo approved treatments · 1 in pipeline

Clinical Trials19 registered · 5 recruiting

Diagnosis

Biomarker and diagnostic research for grade III glioma has been reported in the published literature.

Treatment

Compiled from FDA-approved drug records, orphan drug designations, and FDA Adverse Event Reporting System (FAERS) safety data. GeneReviews management guidance is included where available.

No approved treatments are currently available for grade III glioma. An additional 1 compound holds orphan drug designation.

Orphan Drug Designations

While no drugs are FDA-approved specifically for grade III glioma, some of the following designated compounds may be used off-label in clinical practice. Treatment decisions should be made in consultation with a specialist familiar with this condition.

The following drugs have received orphan drug designation from the FDA for grade III glioma. Orphan designation reflects regulatory interest and does not indicate approval for treatment.

Brand Name	Generic Name	Sponsor

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

19 clinical trials registered, 5 recruiting. Interventions under study include drug therapy, other interventions, procedural interventions, and biologic therapy. Pipeline includes 4 PHASE2, 8 PHASE1, 2 EARLY_PHASE1. Research is sponsored by a mix of industry and academic institutions.

NCT ID	Title	Phase	Sponsor	Status
[NCT04540107](https://clinicaltrials.gov/study/NCT04540107)

Data assembled from 4 of 12 sources · Last updated Sep 18, 2026, 4:17 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

Questions for Your Care Team

→Are any of the 19 active clinical trials a good fit for my situation?
→What is the current development status of Eflornithine, and when might it become available?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

← Back to All Diseases

Research Type	Count	% of Total
Research summaries	3	27%
Clinical study results	3	27%
Laboratory research	2	18%
Disease patterns and progression	2	18%
Testing and diagnosis research	1	9%

grade III glioma

Overview

Diagnosis

Treatment

Orphan Drug Designations

Research Landscape

Medical References

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Clinical Trials

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