IGF1 encodes insulin like growth factor 1 (195 aa). The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. Highest expression in Cervix Endocervix (46.7 TPM) and Cervix Ectocervix (41.2 TPM).

Growth delay due to insulin-like growth factor type 1 deficiency is associated with mutations in the IGF1 gene on chromosome 12.

IGF1 is classified as a druggable target (Clinically Actionable, Druggable Genome, Growth Factor, Hormone Activity, and Kinase categories) with score 13.1.

Genetic testing for IGF1 is available. Testing is considered confirmatory for diagnosis.

Biomarker and diagnostic research for growth delay due to insulin-like growth factor type 1 deficiency has been reported in the published literature.

Phenotype severity distribution: 4 always present features, 20 very common features, 10 common features.

Estimated prevalence: <1 in 1,000,000 (VERY_RARE).

1 clinical trial registered, 1 recruiting. Interventions under study include drug therapy. Research is primarily industry-sponsored.

132 publications have been identified in PubMed for growth delay due to insulin-like growth factor type 1 deficiency. Kisho has analyzed 43 by research type. Research spans Review / Meta-Analysis (37%), Basic Science / Preclinical (26%), and Case Report / Case Series (12%).

Recent Publications

• Yang W (2026). [PMID: 41806600](https://pubmed.ncbi.nlm.nih.gov/41806600/). *Growth Horm IGF Res*. [Review / Meta-Analysis]

• Hu Z (2026). [PMID: 41608982](https://pubmed.ncbi.nlm.nih.gov/41608982/). *Adv Sci (Weinh)*. [Diagnostic / Biomarker]

• Ramon-Krauel M (2026). [PMID: 40626687](https://pubmed.ncbi.nlm.nih.gov/40626687/). *J Clin Endocrinol Metab*. [Epidemiology / Natural History]

• Neshat N (2026). [PMID: 41622549](https://pubmed.ncbi.nlm.nih.gov/41622549/). *Cardiol Rev*. [Review / Meta-Analysis]

• Tailor K (2026). [PMID: 41877483](https://pubmed.ncbi.nlm.nih.gov/41877483/). *Mol Ther*. [Gene Therapy / Novel Therapeutics]

• Erlenhardt N (2026). [PMID: 41177447](https://pubmed.ncbi.nlm.nih.gov/41177447/). *J Mol Cell Cardiol*. [Basic Science / Preclinical]

• Glamočanin T (2026). [PMID: 41976834](https://pubmed.ncbi.nlm.nih.gov/41976834/). *J Clin Med*. [Diagnostic / Biomarker]

• Manni E (2026). [PMID: 41905220](https://pubmed.ncbi.nlm.nih.gov/41905220/). *Cytokine*. [Review / Meta-Analysis]

• Ma X (2025). [PMID: 40964165](https://pubmed.ncbi.nlm.nih.gov/40964165/). *Front Endocrinol (Lausanne)*. [Review / Meta-Analysis]

• Ballester-Rosado CJ (2025). [PMID: 39516073](https://pubmed.ncbi.nlm.nih.gov/39516073/). *Neurotherapeutics*. [Basic Science / Preclinical]