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hearing loss, autosomal dominant 90 - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

hearing loss, autosomal dominant 90

MONDO:0958232

Also known as:deafness, autosomal dominant 90

Overview

GeneticsMYO3A (chr 10)

Genetic Landscape

Assembled from HGNC gene records, ClinGen gene-disease validity evidence, and ClinVar pathogenic variant data. Validity classifications reflect the strength of published evidence linking each gene to this disease.

MYO3A encodes myosin IIIA (1,616 aa). Actin-dependent motor protein with a protein kinase activity, playing an essential role in hearing. Probably also plays a role in vision. Highest expression in Testis (6.3 TPM) and Artery Tibial (2.0 TPM).

Hearing loss, autosomal dominant 90 is associated with mutations in the MYO3A gene on chromosome 10.

MYO3A is classified as a druggable target (Druggable Genome, Enzyme, Kinase, and Serine Threonine Kinase categories) with score 0.0.

Diagnosis

Genetic testing for MYO3A is available. Testing is considered confirmatory for diagnosis.

Biomarker and diagnostic research for hearing loss, autosomal dominant 90 has been reported in the published literature.

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for hearing loss, autosomal dominant 90.

10 publications have been identified in PubMed for hearing loss, autosomal dominant 90. Research spans Case Report / Case Series (30%), Epidemiology / Natural History (30%), and Diagnostic / Biomarker (20%).

Research Type	Count	% of Total
Patient case studies	3	30%

Data assembled from 4 of 12 sources · Last updated Sep 19, 2026, 11:55 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

OMIM

Online Mendelian Inheritance in Man

OMIM:620722

Questions for Your Care Team

→Should I pursue genetic testing for MYO3A, and what would the results mean for my family?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

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hearing loss, autosomal dominant 90

Overview

Genetic Landscape

Diagnosis

Research Landscape

Medical References

External Resources

OMIM

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

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