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Heavy-chain diseases (HCDs) are rare monoclonal lymphoplasma-cell proliferative disorders involving B cells and are characterized by the synthesis of truncated heavy chains without associated light chains.
Biomarker and diagnostic research for heavy chain disease has been reported in the published literature.
Estimated prevalence: Unknown (Unknown prevalence).
No clinical trials have been registered for heavy chain disease.
17 publications have been identified in PubMed for heavy chain disease. Research spans Case Report / Case Series (82%), Other (6%), and Diagnostic / Biomarker (6%).
Research Type | Count | % of Total |
|---|---|---|
Patient case studies | 14 | 82% |
Data assembled from 3 of 12 sources · Last updated Sep 19, 2026, 5:31 AM UTC
European rare disease database
Genetic and Rare Diseases Info Center
1 |
6% |
Testing and diagnosis research | 1 | 6% |
Research summaries | 1 | 6% |
El Boutahiri I (2026). [PMID: 41668820](https://pubmed.ncbi.nlm.nih.gov/41668820/). *European journal of case reports in internal medicine*. [Case Report / Case Series]
Mann MW (2026). [PMID: 41062053](https://pubmed.ncbi.nlm.nih.gov/41062053/). *Clinica chimica acta; international journal of clinical chemistry*. [Case Report / Case Series]
George GV (2026). [PMID: 40611654](https://pubmed.ncbi.nlm.nih.gov/40611654/). *International journal of surgical pathology*. [Other]
Longhi E (2026). [PMID: 41856916](https://pubmed.ncbi.nlm.nih.gov/41856916/). *J Clin Lab Anal*. [Case Report / Case Series]
Kakiuchi S (2026). [PMID: 42135599](https://pubmed.ncbi.nlm.nih.gov/42135599/). *Nephrology (Carlton)*. [Case Report / Case Series]
Davanzo V (2025). [PMID: 39985370](https://pubmed.ncbi.nlm.nih.gov/39985370/). *Clinical chemistry and laboratory medicine*. [Diagnostic / Biomarker]
Amoh BK (2025). [PMID: 41209163](https://pubmed.ncbi.nlm.nih.gov/41209163/). *Kidney Med*. [Case Report / Case Series]
Hanbali A (2025). [PMID: 40700098](https://pubmed.ncbi.nlm.nih.gov/40700098/). *Hematology reports*. [Case Report / Case Series]
Cicerchia C (2025). [PMID: 40838430](https://pubmed.ncbi.nlm.nih.gov/40838430/). *Immunotherapy*. [Case Report / Case Series]
Al-Sawajneh S (2025). [PMID: 40634181](https://pubmed.ncbi.nlm.nih.gov/40634181/). *Clinical lymphoma, myeloma & leukemia*. [Case Report / Case Series]
AI-curated news mentioning heavy chain disease
Updated Mar 19, 2026
A recent case report highlights novel laboratory approaches in diagnosing heavy chain disease, addressing challenges in immunoglobulin quantitation. This study contributes to the understanding of this rare condition and may inform future diagnostic strategies.