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RC3H1 function has not been fully characterized.
Hemophagocytic lymphohistiocytosis, familial, 6 is associated with mutations in the RC3H1 gene on chromosome 1.
Genetic testing for RC3H1 is available. Testing is considered confirmatory for diagnosis.
Biomarker and diagnostic research for hemophagocytic lymphohistiocytosis, familial, 6 has been reported in the published literature.
No clinical trials have been registered for hemophagocytic lymphohistiocytosis, familial, 6.
225 publications have been identified in PubMed for hemophagocytic lymphohistiocytosis, familial, 6. Kisho has analyzed 157 by research type. Research spans Review / Meta-Analysis (25%), Epidemiology / Natural History (22%), and Diagnostic / Biomarker (15%).
Research Type | Count | % of Total |
|---|---|---|
Research summaries | 39 | 25% |
Data assembled from 4 of 12 sources · Last updated Sep 20, 2026, 5:08 AM UTC
Online Mendelian Inheritance in Man
Genetic and Rare Diseases Info Center
Disease patterns and progression |
34 |
22% |
Testing and diagnosis research | 23 | 15% |
Patient case studies | 22 | 14% |
Clinical study results | 18 | 11% |
Laboratory research | 14 | 9% |
New treatment approaches | 4 | 3% |
Other research | 3 | 2% |
Fan P (2026). [PMID: 41652264](https://pubmed.ncbi.nlm.nih.gov/41652264/). *Eur J Pediatr*. [Epidemiology / Natural History]
Guzel SS (2026). [PMID: 41976386](https://pubmed.ncbi.nlm.nih.gov/41976386/). *Cancers (Basel)*. [Epidemiology / Natural History]
Hines MR (2026). [PMID: 41067707](https://pubmed.ncbi.nlm.nih.gov/41067707/). *Transplant Cell Ther*. [Other]
Ortiz-Maldonado V (2026). [PMID: 41651004](https://pubmed.ncbi.nlm.nih.gov/41651004/). *Lancet Haematol*. [Clinical Trial Publication]
Tian M (2026). [PMID: 41886785](https://pubmed.ncbi.nlm.nih.gov/41886785/). *Am J Trop Med Hyg*. [Case Report / Case Series]
Fang Z (2026). [PMID: 41388164](https://pubmed.ncbi.nlm.nih.gov/41388164/). *Am J Hematol*. [Clinical Trial Publication]
Öztürk AG (2026). [PMID: 41437329](https://pubmed.ncbi.nlm.nih.gov/41437329/). *Turk J Haematol*. [Clinical Trial Publication]
Zoref-Lorenz A (2026). [PMID: 41337692](https://pubmed.ncbi.nlm.nih.gov/41337692/). *Blood Adv*. [Case Report / Case Series]
Al-Mashdali AF (2026). [PMID: 42038293](https://pubmed.ncbi.nlm.nih.gov/42038293/). *Front Pharmacol*. [Review / Meta-Analysis]
Lam MT (2026). [PMID: 41638262](https://pubmed.ncbi.nlm.nih.gov/41638262/). *J Allergy Clin Immunol*. [Diagnostic / Biomarker]
AI-curated news mentioning hemophagocytic lymphohistiocytosis, familial, 6
Updated Sep 11, 2026
A systematic review highlights the association between immune checkpoint inhibitors and hemophagocytic lymphohistiocytosis (HLH). This research provides insights into the potential risks of HLH in patients receiving these therapies.
A recent study highlights hemophagocytic lymphohistiocytosis as a potential initial presentation of occult diffuse large B-cell lymphoma, posing significant diagnostic challenges. This finding underscores the need for heightened awareness among clinicians to improve early detection and treatment outcomes.
A recent study highlights hemophagocytic lymphohistiocytosis as a rare complication following systemic Bacillus Calmette-Guérin infection. This finding underscores the need for awareness of this serious condition in patients undergoing common procedures.