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RC3H1 function has not been fully characterized.
Hemophagocytic lymphohistiocytosis, familial, 6 is associated with mutations in the RC3H1 gene on chromosome 1.
Genetic testing for RC3H1 is available. Testing is considered confirmatory for diagnosis.
Biomarker and diagnostic research for hemophagocytic lymphohistiocytosis, familial, 6 has been reported in the published literature.
No clinical trials have been registered for hemophagocytic lymphohistiocytosis, familial, 6.
225 publications have been identified in PubMed for hemophagocytic lymphohistiocytosis, familial, 6. Kisho has analyzed 157 by research type. Research spans Review / Meta-Analysis (25%), Epidemiology / Natural History (22%), and Diagnostic / Biomarker (15%).
Research Type | Count | % of Total |
|---|---|---|
Research summaries | 39 | 25% |
Data assembled from 4 of 12 sources · Last updated Nov 5, 2026, 9:48 AM UTC
Online Mendelian Inheritance in Man
Genetic and Rare Diseases Info Center
Disease patterns and progression |
34 |
22% |
Testing and diagnosis research | 23 | 15% |
Patient case studies | 22 | 14% |
Clinical study results | 18 | 11% |
Laboratory research | 14 | 9% |
New treatment approaches | 4 | 3% |
Other research | 3 | 2% |
Fan P (2026). [PMID: 41652264](https://pubmed.ncbi.nlm.nih.gov/41652264/). *Eur J Pediatr*. [Epidemiology / Natural History]
Guzel SS (2026). [PMID: 41976386](https://pubmed.ncbi.nlm.nih.gov/41976386/). *Cancers (Basel)*. [Epidemiology / Natural History]
Hines MR (2026). [PMID: 41067707](https://pubmed.ncbi.nlm.nih.gov/41067707/). *Transplant Cell Ther*. [Other]
Ortiz-Maldonado V (2026). [PMID: 41651004](https://pubmed.ncbi.nlm.nih.gov/41651004/). *Lancet Haematol*. [Clinical Trial Publication]
Tian M (2026). [PMID: 41886785](https://pubmed.ncbi.nlm.nih.gov/41886785/). *Am J Trop Med Hyg*. [Case Report / Case Series]
Fang Z (2026). [PMID: 41388164](https://pubmed.ncbi.nlm.nih.gov/41388164/). *Am J Hematol*. [Clinical Trial Publication]
Öztürk AG (2026). [PMID: 41437329](https://pubmed.ncbi.nlm.nih.gov/41437329/). *Turk J Haematol*. [Clinical Trial Publication]
Zoref-Lorenz A (2026). [PMID: 41337692](https://pubmed.ncbi.nlm.nih.gov/41337692/). *Blood Adv*. [Case Report / Case Series]
Al-Mashdali AF (2026). [PMID: 42038293](https://pubmed.ncbi.nlm.nih.gov/42038293/). *Front Pharmacol*. [Review / Meta-Analysis]
Lam MT (2026). [PMID: 41638262](https://pubmed.ncbi.nlm.nih.gov/41638262/). *J Allergy Clin Immunol*. [Diagnostic / Biomarker]
AI-curated news mentioning hemophagocytic lymphohistiocytosis, familial, 6
Updated Oct 18, 2026
A case study highlights the presence of occult lymphoma in a 38-year-old woman diagnosed with hemophagocytic lymphohistiocytosis. This discovery may provide insights into the complex relationship between these two conditions.
A recent case report highlights the diagnostic value of skin biopsy in identifying fatal histoplasmosis-associated hemophagocytic lymphohistiocytosis. This study contributes to the understanding of diagnostic approaches for this rare condition.
A case report details a severe instance of Plasmodium vivax malaria complicated by secondary hemophagocytic lymphohistiocytosis, disseminated intravascular coagulation, and acute pancreatitis. This study highlights the complex clinical challenges associated with severe malaria cases.