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hereditary spastic paraplegia 37 (SPG37) - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

hereditary spastic paraplegia 37

MONDO:0012766

Also known as:SPG37autosomal dominant spastic paraplegia 37autosomal dominant spastic paraplegia type 37

Overview

Autosomal dominant spastic paraplegia type 37 is a pure form of hereditary spastic paraplegia characterized by a childhood- to adulthood-onset of slowly progressive spastic gait, extensor plantar responses, brisk tendon reflexes in arms and legs, decreased vibration sense at ankles and urinary dysfunction. Ankle clonus is also reported in some patients.

GeneticsAutosomal dominant

Clinical Presentation

Built from Human Phenotype Ontology (HPO) phenotype annotations and GeneReviews clinical descriptions. Features represent findings documented across known cases — not an exhaustive list of possible symptoms.

Features include sometimes findings: Impaired vibration sensation in the lower limbs, Babinski sign, Ankle clonus, and Upper limb hyperreflexia and others. 11 total HPO annotations.

Organ System	Phenotype Count	Example Features
Brain and nerves	8	Babinski sign, Lower limb hyperreflexia, Spastic gait

Diagnosis

Biomarker and diagnostic research for hereditary spastic paraplegia 37 has been reported in the published literature.

Prognosis

Estimated prevalence: <1 in 1,000,000 (VERY_RARE).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for hereditary spastic paraplegia 37.

12 publications have been identified in PubMed for hereditary spastic paraplegia 37. Research spans Epidemiology / Natural History (42%), Diagnostic / Biomarker (25%), and Case Report / Case Series (17%).

Research Type	Count	% of Total
Disease patterns and progression	5	42%

Data assembled from 5 of 12 sources · Last updated Sep 19, 2026, 9:40 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

OMIM

Online Mendelian Inheritance in Man

OMIM:611945

Orphanet

European rare disease database

Orphanet:171612

GARD

Genetic and Rare Diseases Info Center

GARD:17064

Questions for Your Care Team

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hereditary spastic paraplegia 37

Overview

Clinical Presentation

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

OMIM

Orphanet

GARD

Questions for Your Care Team

Questions for Your Care Team

Explore clinical features

Recent Publications

hereditary spastic paraplegia 37

Overview

Clinical Presentation

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

OMIM

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Explore clinical features

Recent Publications