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high-grade neuroendocrine carcinoma of the corpus uteri - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

high-grade neuroendocrine carcinoma of the corpus uteri

MONDO:0016269

Also known as:high-grade neuroendocrine carcinoma of the uterine corpuspoorly differentiated neuroendocrine carcinoma of the corpus uteripoorly differentiated neuroendocrine carcinoma of the endometrium

Overview

High-grade neuroendocrine carcinoma of the corpus uteri is an extremely rare, aggressive, primary uterine neoplasm, originating from neuroendocrine cells scattered within the endometrium, characterized, macroscopically, by a bulky, frequently polypoid, mass with abundant necrosis located in the uterus and, histologically, by rosette-like and cord-like structures consisting of small, rounded cells with oval nuclei and scarce cytoplasm. Patients often present with dysfunctional uterine bleeding, pelvic or abdominal mass and, especially in later stages of the disease, abdominal pain. Symptomatic metastatic spread or symptoms related to a paraneoplastic syndrome, such as retinopathy, or Cushing syndrome due to ectopic ACTH production, may be associated.

ResearchLimited published research (7 articles)

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for high-grade neuroendocrine carcinoma of the corpus uteri.

7 publications have been identified in PubMed for high-grade neuroendocrine carcinoma of the corpus uteri. Research spans Case Report / Case Series (71%), Other (14%), and Epidemiology / Natural History (14%).

Recent Publications

Aswani A (2026). [PMID: 42005107](https://pubmed.ncbi.nlm.nih.gov/42005107/). *Cureus*. [Case Report / Case Series]
Jin P (2025). [PMID: 41305788](https://pubmed.ncbi.nlm.nih.gov/41305788/). *Medicine*. [Case Report / Case Series]
Pavithran K (2025). [PMID: 41415143](https://pubmed.ncbi.nlm.nih.gov/41415143/). *Journal of mid-life health*. [Case Report / Case Series]
De Wispelaere N (2025). [PMID: 39854331](https://pubmed.ncbi.nlm.nih.gov/39854331/). *PloS one*. [Other]
Faridzi AS (2025). [PMID: 39819883](https://pubmed.ncbi.nlm.nih.gov/39819883/). *The American journal of case reports*. [Case Report / Case Series]

Data assembled from 3 of 12 sources · Last updated Sep 20, 2026, 9:50 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:213731

GARD

Genetic and Rare Diseases Info Center

GARD:20482

Questions for Your Care Team

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high-grade neuroendocrine carcinoma of the corpus uteri

Overview

Research Landscape

Recent Publications

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team