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A rare congenital brain disorder in which the cerebral hemispheres are absent and replaced by sacs that contain cerebrospinal fluid. Signs and symptoms include irritability, increased muscle tone, seizures, and hydrocephalus. The prognosis is poor.
Biomarker and diagnostic research for hydranencephaly has been reported in the published literature.
Estimated prevalence: Unknown (Unknown prevalence).
No clinical trials have been registered for hydranencephaly.
30 publications have been identified in PubMed for hydranencephaly. Research spans Case Report / Case Series (30%), Basic Science / Preclinical (27%), and Epidemiology / Natural History (23%).
Research Type | Count | % of Total |
|---|---|---|
Patient case studies | 9 | 30% |
Data assembled from 3 of 12 sources · Last updated Sep 20, 2026, 8:40 AM UTC
European rare disease database
Genetic and Rare Diseases Info Center
8 |
27% |
Disease patterns and progression | 7 | 23% |
Testing and diagnosis research | 3 | 10% |
Other research | 1 | 3% |
Research summaries | 1 | 3% |
New treatment approaches | 1 | 3% |
Suen WW (2026). [PMID: 41738435](https://pubmed.ncbi.nlm.nih.gov/41738435/). *Veterinary pathology*. [Basic Science / Preclinical]
Windrim C (2026). [PMID: 41553942](https://pubmed.ncbi.nlm.nih.gov/41553942/). *Fetal diagnosis and therapy*. [Review / Meta-Analysis]
Sandoval JI (2026). [PMID: 32644417](https://pubmed.ncbi.nlm.nih.gov/32644417/). *Unknown Journal*. [Other]
Scala M (2026). [PMID: 40133703](https://pubmed.ncbi.nlm.nih.gov/40133703/). *European journal of human genetics : EJHG*. [Basic Science / Preclinical]
Wang J (2026). [PMID: 41514363](https://pubmed.ncbi.nlm.nih.gov/41514363/). *BMC veterinary research*. [Basic Science / Preclinical]
Grassi M (2026). [PMID: 42118806](https://pubmed.ncbi.nlm.nih.gov/42118806/). *Arch Argent Pediatr*. [Case Report / Case Series]
Schollmeyer M (2026). [PMID: 41956352](https://pubmed.ncbi.nlm.nih.gov/41956352/). *Tierarztl Prax Ausg G Grosstiere Nutztiere*. [Case Report / Case Series]
Alarcón A (2025). [PMID: 40653787](https://pubmed.ncbi.nlm.nih.gov/40653787/). *Developmental medicine and child neurology*. [Diagnostic / Biomarker]
Lazarov V (2025). [PMID: 40660053](https://pubmed.ncbi.nlm.nih.gov/40660053/). *Journal of assisted reproduction and genetics*. [Case Report / Case Series]
Fu L (2025). [PMID: 39414989](https://pubmed.ncbi.nlm.nih.gov/39414989/). *Journal of human genetics*. [Case Report / Case Series]