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hydrops fetalis (HF) - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

hydrops fetalis

MONDO:0015193

Also known as:HFfetal anasarcafetal hydrops

Find Clinical TrialsTrials

Overview

Hydrops fetalis is a severe and challenging fetal condition usually defined as the excessive accumulation of fetal fluid within the fetal extravascular compartments and body cavities that manifests as edema, pleural and pericardial effusion and ascites. It is the end-stage of a wide variety of disorders. The cause may be immunologic (immune hydrops fetalis, IHF) or non immunologic (non-immune hydrops fetalis, NIHF), depending on the presence or absence of maternal antibodies against fetal red cell antigens (ABO incompatibility or rhesus (Rh) incompatibility).

OnsetCONGENITAL

Clinical Trials4 registered · 1 recruiting

Diagnosis

Biomarker and diagnostic research for hydrops fetalis has been reported in the published literature.

Prognosis

Estimated prevalence: Unknown (Unknown prevalence).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

4 clinical trials registered, 1 recruiting. Interventions under study include other interventions and gene therapy. Pipeline includes 2 NA. Research is primarily sponsored by academic and government institutions.

279 publications have been identified in PubMed for hydrops fetalis. Kisho has analyzed 212 by research type. Research spans Case Report / Case Series (39%), Review / Meta-Analysis (16%), and Epidemiology / Natural History (14%).

Research Type	Count	% of Total
Patient case studies	82

Data assembled from 4 of 12 sources · Last updated Sep 19, 2026, 11:53 AM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:1041

GARD

Genetic and Rare Diseases Info Center

GARD:2783

Questions for Your Care Team

→Are any of the 4 active clinical trials a good fit for my situation?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

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Kisho

hydrops fetalis

Overview

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Questions for Your Care Team

Questions for Your Care Team

Recent Publications

Latest News & Developments

Enhancing Diagnostic Precision in Non-Immune Hydrops Fetalis: The Incremental Value of Whole Exome Sequencing-A Prospective Cohort Study.

Congenital scrub typhus presenting as non-immune hydrops fetalis.

hydrops fetalis

Overview

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Recent Publications

Latest News & Developments

Enhancing Diagnostic Precision in Non-Immune Hydrops Fetalis: The Incremental Value of Whole Exome Sequencing-A Prospective Cohort Study.

Congenital scrub typhus presenting as non-immune hydrops fetalis.