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Overactive functioning of the spleen, resulting in excessive destruction of blood cells.
Biomarker and diagnostic research for hypersplenism has been reported in the published literature.
5 clinical trials registered, 3 recruiting. Interventions under study include other interventions and procedural interventions. Pipeline includes 2 NA. Research is primarily sponsored by academic and government institutions.
NCT ID | Title | Phase | Sponsor | Status |
|---|---|---|---|---|
[NCT07462091](https://clinicaltrials.gov/study/NCT07462091) |
Data assembled from 3 of 12 sources · Last updated Sep 20, 2026, 1:11 PM UTC
Vagus Nerve-guided Laparoscopic Splenectomy and Azygoportal Disconnection
NA |
Northern Jiangsu People's Hospital |
RECRUITING |
[NCT06292715](https://clinicaltrials.gov/study/NCT06292715) | A Single-Arm Clinical Trial of Percutaneous Splenic Ablation Combined With Splenic Artery Occlusion for Secondary Hypersplenism. | NA | Tianjin Medical University Cancer Institute and Hospital | RECRUITING |
[NCT07585773](https://clinicaltrials.gov/study/NCT07585773) | Effect of Laparoscopic Splenectomy on Renal Function in Cirrhotic Patients With Hypersplenism (2-Year Follow-Up) | — | Northern Jiangsu People's Hospital | NOT_YET_RECRUITING |
[NCT07588373](https://clinicaltrials.gov/study/NCT07588373) | Effect of Laparoscopic Splenectomy on Lipid Profiles in Cirrhotic Patients With Hypersplenism (2-Year Follow-Up) | — | Northern Jiangsu People's Hospital | NOT_YET_RECRUITING |
[NCT07811687](https://clinicaltrials.gov/study/NCT07811687) | Effect of Laparoscopic Hepatectomy Combined With Splenectomy on Hepatic Functional Reserve and Immune Function | — | Northern Jiangsu People's Hospital | RECRUITING |
150 publications have been identified in PubMed for hypersplenism. Research spans Case Report / Case Series (38%), Clinical Trial Publication (24%), and Epidemiology / Natural History (18%).
Research Type | Count | % of Total |
|---|---|---|
Patient case studies | 57 | 38% |
Clinical study results | 36 | 24% |
Disease patterns and progression | 27 | 18% |
Research summaries | 15 | 10% |
Laboratory research | 7 | 5% |
Testing and diagnosis research | 4 | 3% |
Other research | 3 | 2% |
New treatment approaches | 1 | 1% |
Chhetri PK (2026). [PMID: 42245413](https://pubmed.ncbi.nlm.nih.gov/42245413/). *J Surg Case Rep*. [Case Report / Case Series]
Zheng RF (2026). [PMID: 42246677](https://pubmed.ncbi.nlm.nih.gov/42246677/). *Lupus*. [Epidemiology / Natural History]
Luoto T (2026). [PMID: 41797393](https://pubmed.ncbi.nlm.nih.gov/41797393/). *Liver Int*. [Epidemiology / Natural History]
Kumar B (2026). [PMID: 41958788](https://pubmed.ncbi.nlm.nih.gov/41958788/). *J Indian Assoc Pediatr Surg*. [Case Report / Case Series]
Ye QQ (2026). [PMID: 41661299](https://pubmed.ncbi.nlm.nih.gov/41661299/). *Ann Hematol*. [Case Report / Case Series]
Shi X (2026). [PMID: 42243705](https://pubmed.ncbi.nlm.nih.gov/42243705/). *BMC Gastroenterol*. [Epidemiology / Natural History]
Liu B (2026). [PMID: 42241173](https://pubmed.ncbi.nlm.nih.gov/42241173/). *J Cancer Res Ther*. [Clinical Trial Publication]
Amirbeigy MK (2026). [PMID: 41606599](https://pubmed.ncbi.nlm.nih.gov/41606599/). *Thromb J*. [Case Report / Case Series]
Barnes-Navarro D (2026). [PMID: 41673167](https://pubmed.ncbi.nlm.nih.gov/41673167/). *Cardiovasc Intervent Radiol*. [Clinical Trial Publication]
Salinas-Castro KJ (2026). [PMID: 41929407](https://pubmed.ncbi.nlm.nih.gov/41929407/). *Front Radiol*. [Clinical Trial Publication]
AI-curated news mentioning hypersplenism
Updated Sep 11, 2026
A recent study highlights pediatric hepatic sarcoidosis as a rare cause of hypersplenism and portal hypertension in children. This discovery emphasizes the need for awareness and further research into this uncommon presentation.
A case study highlights a rare presentation of hypersplenism in an adult female with homozygous sickle cell disease. This discovery may provide insights into the complications associated with sickle cell disease.