Kisho

Kisho is an information platform, not a medical provider. Nothing on this site constitutes medical advice, diagnosis, or treatment recommendations. All content is aggregated from publicly available sources (including ClinicalTrials.gov, PubMed, FDA.gov, and Orphanet) and is provided for informational purposes only. Clinical trial eligibility, treatment decisions, and any health-related actions should always be discussed with a qualified healthcare professional. Kisho does not endorse any specific therapy, organization, or clinical trial. Terms of use · Privacy policy

hypothalamic hamartomas with gelastic seizures - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

hypothalamic hamartomas with gelastic seizures

MONDO:0019484

Overview

A rare cerebral malformation with epilepsy syndrome characterized by early-onset gelastic (i.e. ictal laughter) or dacrystic (i.e., ictal crying) seizures due to non-neoplastic developmental malformation - hypothalamic hamartomas. In many patients, seizures progress to other seizure types including focal and generalized seizures, with concomitant cognitive decline and behavioral disorders. Some patients also present a precocious puberty.

Diagnosis

Biomarker and diagnostic research for hypothalamic hamartomas with gelastic seizures has been reported in the published literature.

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for hypothalamic hamartomas with gelastic seizures.

30 publications have been identified in PubMed for hypothalamic hamartomas with gelastic seizures. Research spans Clinical Trial Publication (28%), Diagnostic / Biomarker (21%), and Review / Meta-Analysis (21%).

Research Type	Count	% of Total
Clinical study results	8	28%

Data assembled from 3 of 12 sources · Last updated Sep 20, 2026, 4:02 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:86906

GARD

Genetic and Rare Diseases Info Center

GARD:19084

Questions for Your Care Team

→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

← Back to All Diseases

hypothalamic hamartomas with gelastic seizures

Overview

Diagnosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Recent Publications