LIPH encodes lipase H (451 aa). Hydrolyzes specifically phosphatidic acid (PA) to produce 2-acyl lysophosphatidic acid (LPA; a potent bioactive lipid mediator) and fatty acid. Highest expression in Stomach (28.5 TPM) and Minor Salivary Gland (19.9 TPM).

Hypotrichosis 7 is associated with mutations in the LIPH gene on chromosome 3.

The LIPH protein participates in LIPH, I hydrolyse PA to 2-acyl LPA and Trunk bipotent pancreatic progenitor cell produces pancreatic ductal cell pathways.

LIPH is classified as a druggable target (Druggable Genome, Lipase, and Phospholipase categories) with score 0.0.

Genetic testing for LIPH is available. Testing is considered confirmatory for diagnosis.

Phenotype severity distribution: 7 always present features.

No clinical trials have been registered for hypotrichosis 7.

31 publications have been identified in PubMed for hypotrichosis 7. Research spans Review / Meta-Analysis (26%), Basic Science / Preclinical (19%), and Epidemiology / Natural History (19%).

Recent Publications

• Mao G (2026). [PMID: 41703066](https://pubmed.ncbi.nlm.nih.gov/41703066/). *Aesthetic Plast Surg*. [Basic Science / Preclinical]

• Behrangi E (2026). [PMID: 41987228](https://pubmed.ncbi.nlm.nih.gov/41987228/). *Stem Cell Res Ther*. [Review / Meta-Analysis]

• Alwunais K (2026). [PMID: 40457931](https://pubmed.ncbi.nlm.nih.gov/40457931/). *Dermatol Reports*. [Case Report / Case Series]

• Gupta P (2026). [PMID: 39912188](https://pubmed.ncbi.nlm.nih.gov/39912188/). *Indian J Dermatol Venereol Leprol*. [Other]

• van Hensbergen I (2026). [PMID: 41705568](https://pubmed.ncbi.nlm.nih.gov/41705568/). *Vet Dermatol*. [Basic Science / Preclinical]

• Kim YN (2026). [PMID: 41761855](https://pubmed.ncbi.nlm.nih.gov/41761855/). *ChemistryOpen*. [Basic Science / Preclinical]

• Shimomura Y (2025). [PMID: 37407443](https://pubmed.ncbi.nlm.nih.gov/37407443/). *Keio J Med*. [Review / Meta-Analysis]

• Järvinen A (2025). [PMID: 40551423](https://pubmed.ncbi.nlm.nih.gov/40551423/). *Acta Derm Venereol*. [Epidemiology / Natural History]

• Liu RH (2025). [PMID: 39179656](https://pubmed.ncbi.nlm.nih.gov/39179656/). *Aesthetic Plast Surg*. [Epidemiology / Natural History]

• Alotaibi HM (2025). [PMID: 40153034](https://pubmed.ncbi.nlm.nih.gov/40153034/). *Arch Dermatol Res*. [Epidemiology / Natural History]